Docosatetraenoic acid
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| IUPAC name
7Z,10Z,13Z,16Z-docosatetraenoic acid | |
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| Properties | |
| C22H36O2 | |
| Molar mass | 332.5 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is  ?) | |
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Docosatetraenoic acid designates any straight chain 22:4 fatty acid. (See essential fatty acid for nomenclature.)
One isomer is of particular interest:
- all-cis-7,10,13,16-docosatetraenoic acid is an ω-6 fatty acid with the trivial name adrenic acid(AdA). This is a naturally occurring polyunsaturated fatty acid formed through a 2-carbon chain elongation of arachidonic acid. It is one of the most abundant fatty acids in the early human brain.[1] This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins,[2] dihomo-epoxyeicosatrienoic acids, [3] and dihomo-EETs.[4]
See also
References
- ↑ Martinez M (1992). "Tissue levels of polyunsaturated fatty acids during early human development". J Pediatr. 120 (4 Pt 2): S129–38. PMID 1532827. doi:10.1016/S0022-3476(05)81247-8.
- ↑ Campbell WB, Falck JR, Okita JR, Johnson AR, Callahan KS (1985). "Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells". Biochim. Biophys. Acta. 837 (1): 67–76. PMID 3931686. doi:10.1016/0005-2760(85)90086-4.
- ↑ Kopf PG, Zhang DX, Gauthier KM, Nithipatikom K, Yi XY, Falck JR, Campbell WB (2010). "Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors". Hypertension. 55 (2): 547–54. PMC 2819927
. PMID 20038752. doi:10.1161/HYPERTENSIONAHA.109.144147. - ↑ Yi XY, Gauthier KM, Cui L, Nithipatikom K, Falck JR, Campbell WB (May 2007). "Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries.". Am J Physiol Heart Circ Physiol. 292 (5): H2265–74. PMID 17209008. doi:10.1152/ajpheart.00947.2006.
Further reading
- Ferretti, A., Flanagan, V.P. Mass spectrometric evidence for the conversion of exogenous adrenate to dihomo-prostaglandins by seminal vesicle cyclo-oxygenase. A comparative study of two animal species. J Chromatogr 383 241-250 (1986).
- Sprecher, H., VanRollins, M., Sun, F., et al. Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. J Biol Chem 257 3912-3918 (1982).
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