Adenosine diphosphate ribose

Adenosine diphosphate ribose
Names


Other names ADP ribose
Identifiers
CAS Number	20762-30-5^N
3D model (JSmol)	Interactive image
ChemSpider	388340^N
MeSH	Adenosine+Diphosphate+Ribose
PubChem CID	439200
InChI InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1^N Key: YNCNQNWXUFCWJS-DKMYFHGXSA-O^N InChI=1/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1 Key: YNCNQNWXUFCWJS-LKOYDKQFBH
SMILES O=P(O[C@H]1O[C@H]([C@H](O)[C@@H]1O)CO)(O)OP(=O)(OC[C@H]4O[C@@H]([n+]3c2ncnc(N)c2nc3)[C@H](O)[C@@H]4O)O
Properties
Chemical formula	C₁₅H₂₃N₅O₁₄P₂
Molar mass	559.316 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. It binds to and activates the TRPM2 ion channel.^[1]

References

↑ Fonfria E, Marshall IC, Benham CD, et al. (September 2004). "TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase". Br. J. Pharmacol. 143 (1): 186–92. PMC 1575275 . PMID 15302683. doi:10.1038/sj.bjp.0705914.

TRP channel modulators

TRPA

Activators

4-Hydroxynonenal
4-Oxo-2-nonenal
4,5-EET
12S-HpETE
15-Deoxy-Δ^12,14-prostaglandin J2
α-Sanshool (ginger, Sichuan and melegueta peppers)
Acrolein
Allicin (garlic)
Allyl isothiocyanate (mustard, radish, horseradish, wasabi)
AM404
Bradykinin
Cannabichromene (cannabis)
Cannabidiol (cannabis)
Cannabigerol (cannabis)
Cinnamaldehyde (cinnamon)
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Curcumin (turmeric)
Dehydroligustilide (celery)
Diallyl disulfide
Dicentrine (Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (ginger)
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
Ligustilide (celery, Angelica acutiloba)
Linalool (Sichuan pepper, thyme)
Methylglyoxal
Methyl salicylate (wintergreen)
N-Methylmaleimide
Nicotine (tobacco)
Oleocanthal (olive oil)
Paclitaxel (Pacific yew)
Paracetamol (acetaminophen)
PF-4840154
Phenacyl chloride
Polygodial (Dorrigo pepper)
Shogaols (ginger, Sichuan and melegueta peppers)
Tear gases
Tetrahydrocannabinol (cannabis)
Thiopropanal S-oxide (onion)
Umbellulone (Umbellularia californica)
WIN 55,212-2

Blockers

Dehydroligustilide (celery)
Nicotine (tobacco)
Ruthenium red

TRPC

Activators	Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P
Blockers	DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid

TRPM

Activators

ADP-ribose
BCTC
Calcium (intracellular)
Cold
Coolact P
Cooling Agent 10
CPS-369
Eucalyptol (eucalyptus)
Frescolat MGA
Frescolat ML
Geraniol
Hydroxycitronellal
Icilin
Linalool
Menthol (mint)
PMD 38
Pregnenolone sulfate
Rutamarin (Ruta graveolens)
Steviol glycosides (e.g., stevioside) (Stevia rebaudiana)
Sweet tastants (e.g., glucose, fructose, sucrose; indirectly)
Thio-BCTC
WS-3
WS-12
WS-23

Blockers

TRPML

Activators	MK6-83 PI(3,5)P₂ SF-22

TRPP

Activators	Triptolide (Tripterygium wilfordii)
Blockers	Ruthenium red

TRPV

Activators

2-APB
5',6'-EET
9-HODE
9-oxoODE
12S-HETE
12S-HpETE
13-HODE
13-oxoODE
20-HETE
α-Sanshool (ginger, Sichuan and melegueta peppers)
Allicin (garlic)
AM404
Anandamide
Bisandrographolide (Andrographis paniculata)
Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil)
Cannabidiol (cannabis)
Cannabidivarin (cannabis)
Capsaicin (chili pepper)
Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
DHEA
Diacyl glycerol
Dihydrocapsaicin (chili pepper)
Estradiol
Eugenol (basil, clove)
Evodiamine (Euodia ruticarpa)
Gingerols (ginger)
GSK1016790A
Heat
Hepoxilin A3
Hepoxilin B3
Homocapsaicin (chili pepper)
Homodihydrocapsaicin (chili pepper)
Incensole (incense)
Lysophosphatidic acid
Low pH (acidic conditions)
Menthol (mint)
N-Arachidonoyl dopamine
N-Oleoyldopamine
N-Oleoylethanolamide
Nonivamide (PAVA) (PAVA spray)
Nordihydrocapsaicin (chili pepper)
Paclitaxel (Pacific yew)
Paracetamol (acetaminophen)
Phorbol esters (e.g., 4α-PDD)
Piperine (black pepper, long pepper)
Polygodial (Dorrigo pepper)
Probenecid
Protons
Rutamarin (Ruta graveolens)
Resiniferatoxin (RTX) (Euphorbia resinifera/pooissonii)
Shogaols (ginger, Sichuan and melegueta peppers)
Tetrahydrocannabivarin (cannabis)
Thymol (thyme, oregano)
Tinyatoxin (Euphorbia resinifera/pooissonii)
Tramadol
Vanillin (vanilla)
Zucapsaicin

Blockers

α-Spinasterol (Vernonia tweediana)
AMG-517
BCTC
Cannabigerol (cannabis)
Cannabigerolic acid (cannabis)
Cannabigerovarin (cannabis)
Cannabinol (cannabis)
Capsazepine
DCDPC
DHEA
DHEA-S
Flufenamic acid
GRC-6211
HC-067047
Lanthanum
Meclofenamic acid
N-(p-amylcinnamoyl)anthranilic acid
NGD-8243
Niflumic acid
Pregnenolone sulfate
RN-1734
RN-9893
Ruthenium red
SB-705498
Tolfenamic acid

See also: Receptor/signaling modulators • Ion channel modulators

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