Acenocoumarol

Acenocoumarol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	X
Routes of administration	Oral
ATC code	B01AA07 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	8 to 11 hours
Identifiers
IUPAC name (RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
CAS Number	152-72-7 Y
PubChem CID	9052
DrugBank	DB01418 Y
ChemSpider	10443441 Y
UNII	I6WP63U32H
KEGG	D07064 Y
ChEBI	CHEBI:53766 Y
ChEMBL	CHEMBL397420 Y
ECHA InfoCard	100.005.281
Chemical and physical data
Formula	C19H15NO6
Molar mass	353.326 g/mol
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
Melting point	196 to 199 °C (385 to 390 °F)
SMILES [O-][N+](=O)c1ccc(cc1)C(CC(C)=O)C\2=C(/O)c3ccccc3OC/2=O
InChI InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3 Y Key:VABCILAOYCMVPS-UHFFFAOYSA-N Y
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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.^[1]

References

External links

• DDB 29202

• Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis. 15 (8): 673–6. PMID 15613922. doi:10.1097/00001721-200412000-00007. 
• Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil. 145 (52): 2619–21. PMID 15724697. 
• Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet. 44 (12): 1227–46. PMID 16372822. doi:10.2165/00003088-200544120-00003. 
• Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol. 133 (2): 183–7. PMID 16611310. doi:10.1111/j.1365-2141.2006.06007.x.