AZGP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1T7V, 1T7W, 1T7X, 1T7Y, 1T7Z, 1T80, 1ZAG, 3ES6

Identifiers

Aliases

AZGP1, ZA2G, ZAG, alpha-2-glycoprotein 1, zinc-binding

External IDs

MGI: 103163 HomoloGene: 915 GeneCards: AZGP1

Gene ontology
Molecular function	• protein transmembrane transporter activity • ribonuclease activity • protein binding
Cellular component	• plasma membrane • extracellular region • extracellular exosome • nucleus • extracellular space
Biological process	• detection of chemical stimulus involved in sensory perception of bitter taste • retina homeostasis • cell adhesion • transmembrane transport • negative regulation of cell proliferation • protein transmembrane transport • RNA phosphodiester bond hydrolysis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


563


12007

Ensembl


ENSG00000160862


ENSMUSG00000037053

UniProt


P25311


Q64726

RefSeq (mRNA)


NM_001185


NM_013478

RefSeq (protein)


NP_001176


NP_038506

Location (UCSC)

Chr 7: 99.97 – 99.98 Mb

Chr 5: 137.98 – 137.99 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.^[3]^[4]

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.^[5] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.^[5] Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. PMID 2049092. doi:10.1016/0006-291X(91)91844-3.
↑ "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding".
1 2 Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH; et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. PMC 2679098 . PMID 19188554. doi:10.1378/chest.08-1024.

External links

Human AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser.

Freije JP, Fueyo A, Uría J, López-Otín C (1991). "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues.". FEBS Lett. 290 (1–2): 247–9. PMID 1915885. doi:10.1016/0014-5793(91)81271-9.
Tada T, Ohkubo I, Niwa M, et al. (1991). "Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues". J. Histochem. Cytochem. 39 (9): 1221–6. PMID 1918940. doi:10.1177/39.9.1918940.
Araki T, Gejyo F, Takagaki K, et al. (1988). "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens". Proc. Natl. Acad. Sci. U.S.A. 85 (3): 679–83. PMC 279618 . PMID 3422450. doi:10.1073/pnas.85.3.679.
Shibata S, Miura K (1982). "Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine". Nephron. 31 (2): 170–6. PMID 6896906. doi:10.1159/000182638.
Ueyama H, Deng HX, Ohkubo I (1994). "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein". Biochemistry. 32 (48): 12968–76. PMID 8241150. doi:10.1021/bi00211a004.
Freije JP, Fueyo A, Uría JA, et al. (1994). "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes". Genomics. 18 (3): 575–87. PMID 8307568. doi:10.1016/S0888-7543(05)80359-3.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Sánchez LM, López-Otín C, Bjorkman PJ (1997). "Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4626–30. PMC 20774 . PMID 9114041. doi:10.1073/pnas.94.9.4626.
Brysk MM, Lei G, Rajaraman S, et al. (1997). "Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia". In Vivo. 11 (3): 271–4. PMID 9239523.
Lei G, Arany I, Selvanayagam P, et al. (1997). "Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors". J. Cell. Biochem. 67 (2): 216–22. PMID 9328826. doi:10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-#.
Ogikubo O, Maeda T, Yamane T, et al. (1998). "Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives". Biochem. Biophys. Res. Commun. 252 (1): 257–62. PMID 9813179. doi:10.1006/bbrc.1998.9614.
Sánchez LM, Chirino AJ, Bjorkman P (1999). "Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules". Science. 283 (5409): 1914–9. PMID 10206894. doi:10.1126/science.283.5409.1914.
Lei G, Brysk H, Arany I, et al. (1999). "Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line". J. Cell. Biochem. 75 (1): 160–9. PMID 10462714. doi:10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B.
Davidsson P, Nilsson CL (2000). "Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry". Biochim. Biophys. Acta. 1473 (2–3): 391–9. PMID 10594376. doi:10.1016/s0304-4165(99)00197-x.
Kennedy MW, Heikema AP, Cooper A, et al. (2001). "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins". J. Biol. Chem. 276 (37): 35008–13. PMID 11425849. doi:10.1074/jbc.C100301200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
BURGI W, SCHMID K (1998). "Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma". J. Biol. Chem. 236: 1066–74. PMID 13689030.

PDB gallery

1t7v: Zn-alpha-2-glycoprotein; baculo-ZAG PEG 200

1t7w: Zn-alpha-2-glycoprotein; CHO-ZAG PEG 400

1t7x: Zn-alpha-2-glycoprotein; refolded CHO-ZAG PEG 400

1t7y: Zn-alpha-2-glycoprotein; baculo-ZAG PEG 200, no glycerol

1t7z: Zn-alpha-2-glycoprotein; baculo-ZAG no PEG, no glycerol

1t80: Zn-alpha-2-glycoprotein; CHO-ZAG PEG 200

1zag: HUMAN ZINC-ALPHA-2-GLYCOPROTEIN

2icn:

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AZGP1

References

External links

Further reading