ATP6V1E2

ATP6V1E2

Identifiers

ATP6V1E2, ATP6E1, ATP6EL2, ATP6V1EL2, VMA4, ATPase H+ transporting V1 subunit E2

External IDs

MGI: 1922165 HomoloGene: 41770 GeneCards: ATP6V1E2

Gene ontology
Molecular function	• hydrogen-exporting ATPase activity, phosphorylative mechanism • protein binding • proton-transporting ATPase activity, rotational mechanism
Cellular component	• cytosol • acrosomal vesicle • proton-transporting two-sector ATPase complex, catalytic domain
Biological process	• insulin receptor signaling pathway • ion transmembrane transport • ATP hydrolysis coupled proton transport • ion transport • proton transport • transferrin transport • regulation of macroautophagy • phagosome acidification • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


90423


74915


ENSG00000250565


ENSMUSG00000053375


Q96A05


Q9D593

RefSeq (mRNA)


NM_080653 NM_001318063


NM_029121

RefSeq (protein)


NP_001304992


NP_083397

Location (UCSC)

Chr 2: 46.49 – 46.54 Mb

Chr 17: 86.94 – 86.95 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Imai-Senga Y, Sun-Wada GH, Wada Y, Futai M (May 2002). "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E". Gene. 289 (1–2): 7–12. PMID 12036578. doi:10.1016/S0378-1119(02)00542-5.
↑ "Entrez Gene: ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2".

External links

Human ATP6V1E2 genome location and ATP6V1E2 gene details page in the UCSC Genome Browser.

Further reading

Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. PMID 11836511. doi:10.1038/nrm729.
Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. PMID 12788495. doi:10.1016/S0014-5793(03)00396-X.
Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. PMID 14597263. doi:10.1016/S0248-4900(03)00075-3.
Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. PMID 10748165. doi:10.1074/jbc.M909857199.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Smith AN, Lovering RC, Futai M, et al. (2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol. Cell. 12 (4): 801–3. PMID 14580332. doi:10.1016/S1097-2765(03)00397-6.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.

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