Activating transcription factor 2

ATF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BHI, 1T2K, 4H36
Identifiers
Aliases	ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2
External IDs	MGI: 109349 HomoloGene: 31061 GeneCards: ATF2
Gene ontology Molecular function • transferase activity • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • cAMP response element binding protein binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • chromatin binding • metal ion binding • RNA polymerase II activating transcription factor binding • transcription factor activity, RNA polymerase II transcription factor binding • protein binding • enhancer sequence-specific DNA binding • protein heterodimerization activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein kinase binding • cAMP response element binding • histone acetyltransferase activity Cellular component • cytoplasm • membrane • nucleoplasm • mitochondrial outer membrane • mitochondrion • nucleus • site of double-strand break Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • intra-S DNA damage checkpoint • outflow tract morphogenesis • response to water deprivation • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • positive regulation of transforming growth factor beta2 production • transcription, DNA-templated • cellular response to DNA damage stimulus • response to osmotic stress • positive regulation of neuron apoptotic process • regulation of sequence-specific DNA binding transcription factor activity • positive regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of epithelial cell proliferation • adipose tissue development • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • amelogenesis • histone acetylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1386	11909
Ensembl	ENSG00000115966	ENSMUSG00000027104
UniProt	P15336	P16951
RefSeq (mRNA)	NM_001256090 NM_001256091 NM_001256092 NM_001256093 NM_001256094 NM_001880	NM_001025093 NM_001284369 NM_001284370 NM_001284371 NM_001284372 NM_001284373 NM_001284374 NM_001284376 NM_009715
RefSeq (protein)	NP_001243019 NP_001243020 NP_001243021 NP_001243022 NP_001243023 NP_001871	NP_001020264 NP_001271298 NP_001271299 NP_001271300 NP_001271301 NP_001271302 NP_001271303 NP_001271305 NP_033845
Location (UCSC)	Chr 2: 175.07 – 175.17 Mb	Chr 2: 73.82 – 73.89 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.^[3]

Function

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus, it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.^[3]

The gene atf2 is located at human chromosome 2q32.^[4] The protein ATF-2 has 505 amino acids. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton.^[5] ATF-2 is normally activated in response to signals that converge on stress-activated protein kinases p38 and JNK.^[6] ATF-2 phosphorylation in response to treatment of cells with tumor promoter phorbol ester has been demonstrated.^[7]

Several studies implicate abnormal activation of ATF-2 in growth and progression of mammalian skin tumors.^[8][9] ATF-2 may mediate oncogenesis caused by mutant Ras protein^[10] and regulate maintenance of the aggressive cancer phenotype of some types of epithelial cells. ATF2 has also been shown to be phosphorylated at its C-terminal (Serine 472 and 480 in mouse; Serine 490 and 498 in human) by ATM upon double-stranded breaks. Mice with mutations of these two serines are sensitive to irradiation and easier to tumorigenesis under p53 knockout background.

ATF2 has also been shown to be phosphorylated at its C-terminal (serine 472 and 480 in mouse; serine 490 and 498 in human) by ATM upon double-stranded breaks.^[11]

Interactions

Activating transcription factor 2 has been shown to interact with

• C-jun,^[12][13][14]
• Casein kinase 2, alpha 1,^[15]
• CREB binding protein,^[16]
• CSNK2A2,^[15]
• JDP2,^[17]
• MAPK14,^[18][19][20]
• MAPK8,^{[18][19][20][21]}
• Mothers against decapentaplegic homolog 3^[22]
• NCOA6,^[23]
• RUVBL2,^[24]
• UBE2I.^[25]

See also

• Activating transcription factor

References

External links

• Human ATF2 genome location and ATF2 gene details page in the UCSC Genome Browser.

Further reading

PDB gallery
1bhi: STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES  1t2k: Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA