ASAH2B
| ASAH2B | |||||||
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| Identifiers | |||||||
| Aliases | ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B | ||||||
| External IDs | GeneCards: ASAH2B | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | Chr 10: 50.74 – 50.82 Mb | n/a | |||||
| PubMed search | [1] | n/a | |||||
| Wikidata | |||||||
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Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.[2][3]
Clinical significance
ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.[2]
References
- ↑ "Human PubMed Reference:".
- 1 2 Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. PMID 17334805. doi:10.1007/s10048-007-0081-5.
- ↑ Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. PMID 15164054. doi:10.1038/nature02462.
External links
- Human ASAH2B genome location and ASAH2B gene details page in the UCSC Genome Browser.
Further reading
- Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971.
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