ARHGEF3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Z0Q

Identifiers

Aliases

ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3

External IDs

MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3

Gene ontology
Molecular function	• Rho guanyl-nucleotide exchange factor activity • protein binding • guanyl-nucleotide exchange factor activity
Cellular component	• cytoplasm • cytosol • intracellular
Biological process	• regulation of Rho protein signal transduction • intracellular signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • positive regulation of apoptotic process • positive regulation of GTPase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


50650


71704

Ensembl


ENSG00000163947


ENSMUSG00000021895

UniProt


Q9NR81


Q91X46

RefSeq (mRNA)


NM_001128615 NM_001128616 NM_001289698 NM_019555


NM_001289686 NM_001289687 NM_001289688 NM_027871

RefSeq (protein)


NP_001122087 NP_001122088 NP_001276627 NP_062455


NP_001276615 NP_001276616 NP_001276617 NP_082147

Location (UCSC)

Chr 3: 56.73 – 57.08 Mb

Chr 14: 27.24 – 27.4 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.^[3]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.^[3]

Interactions

ARHGEF3 has been shown to interact with RHOA^[4] and RHOB.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
1 2 Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. PMID 12221096. doi:10.1074/jbc.M207401200.

External links

Human ARHGEF3 genome location and ARHGEF3 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. PMID 10873612. doi:10.1006/bbrc.2000.2925.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. PMID 12221096. doi:10.1074/jbc.M207401200.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.

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ARHGEF3

Function

Interactions

References

External links

Further reading