ARHGDIG

Identifiers

ARHGDIG, RHOGDI-3, Rho GDP dissociation inhibitor gamma

External IDs

MGI: 108430 HomoloGene: 7337 GeneCards: ARHGDIG

Gene ontology
Molecular function	• GDP-dissociation inhibitor activity • Rho GDP-dissociation inhibitor activity • protein binding • GTPase regulator activity • GTPase activator activity
Cellular component	• cytoplasm • cytosol • membrane • cytoplasmic vesicle
Biological process	• negative regulation of cell adhesion • positive regulation of GTPase activity • regulation of catalytic activity • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of protein localization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


398


14570

Ensembl


ENSG00000242173


ENSMUSG00000073433

UniProt


Q99819


Q62160

RefSeq (mRNA)


NM_001176


NM_008113

RefSeq (protein)


NP_001167


NP_032139

Location (UCSC)

Chr 16: 0.27 – 0.28 Mb

Chr 17: 26.2 – 26.21 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.^[3]^[4]^[5]

Interactions

ARHGDIG has been shown to interact with RHOB.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B (May 1997). "RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas". Proc Natl Acad Sci U S A. 94 (9): 4279–84. PMC 20713 . PMID 9113980. doi:10.1073/pnas.94.9.4279.
↑ Brunet N, Morin A, Olofsson B (Apr 2002). "RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain". Traffic. 3 (5): 342–57. PMID 11967128. doi:10.1034/j.1600-0854.2002.30504.x.
↑ "Entrez Gene: ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma".
↑ Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. PMID 8939998. doi:10.1074/jbc.271.48.30366.

External links

Human ARHGDIG genome location and ARHGDIG gene details page in the UCSC Genome Browser.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. PMID 8939998. doi:10.1074/jbc.271.48.30366.
Adra CN, Iyengar AR, Syed FA, Kanaan IN, Rilo HL, Yu W, Kheraj R, Lin SR, Horiuchi T, Khan S, Weremowicz S, Lim B, Morton CC, Higgs DR (1998). "Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3". Genomics. 53 (1): 104–9. PMID 9787082. doi:10.1006/geno.1998.5482.
Elenich LA, Nandi D, Kent AE, McCluskey TS, Cruz M, Iyer MN, Woodward EC, Conn CW, Ochoa AL, Ginsburg DB, Monaco JJ (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics. 49 (10): 835–42. PMID 10436176. doi:10.1007/s002510050562.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797. doi:10.1093/hmg/10.4.339.
Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. 22 (4): 1158–71. PMC 134637 . PMID 11809807. doi:10.1128/MCB.22.4.1158-1171.2002.
del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA (2004). "Integrins regulate Rac targeting by internalization of membrane domains". Science. 303 (5659): 839–42. PMID 14764880. doi:10.1126/science.1092571.
Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors". J. Biol. Chem. 280 (6): 4674–83. PMID 15513926. doi:10.1074/jbc.M409741200.

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ARHGDIG

Interactions

References

External links

Further reading