APBA2BP
| NECAB3 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3 | ||||||||||||||||
| External IDs | MGI: 1861721 HomoloGene: 10992 GeneCards: NECAB3 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 20: 33.66 – 33.67 Mb | Chr 2: 154.54 – 154.56 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[3][4]
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem. 275 (30): 23134–8. PMID 10833507. doi:10.1074/jbc.C000302200.
- 1 2 "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".
External links
- Human NECAB3 genome location and NECAB3 gene details page in the UCSC Genome Browser.
Further reading
- Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.". Nucleic Acids Res. 26 (21): 5007–8. PMC 147919
. PMID 9776767. doi:10.1093/nar/26.21.5007. - Sugita S, Südhof TC (2000). "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.". Biochemistry. 39 (11): 2940–9. PMID 10715114. doi:10.1021/bi9920984.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
- Sugita S, Ho A, Südhof TC (2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.". Neuroscience. 112 (1): 51–63. PMID 12044471. doi:10.1016/S0306-4522(02)00063-5.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Sumioka A, Imoto S, Martins RN, et al. (2003). "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.". Biochem. J. 374 (Pt 1): 261–8. PMC 1223589 . PMID 12780348. doi:10.1042/BJ20030489.
- Yoo JC, Chang JR, Kim SH, et al. (2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.". Exp. Cell Res. 292 (2): 393–402. PMID 14697346. doi:10.1016/j.yexcr.2003.09.025.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
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