Synergin gamma
Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.[5][6]
Function
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.[6]
Interactions
AP1GBP1 has been shown to interact with AP1G1[7][8] and SCAMP1.[9]
References
- 1 2 3 ENSG00000274047 GRCh38: Ensembl release 89: ENSG00000275066, ENSG00000274047 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034940 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Page LJ, Sowerby PJ, Lui WW, Robinson MS (October 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. PMC 2169493 . PMID 10477754. doi:10.1083/jcb.146.5.993.
- 1 2 "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1".
- ↑ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. PMID 12042876. doi:10.1038/nsb808.
- ↑ Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. PMID 10814529. doi:10.1006/bbrc.2000.2700.
- ↑ Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. PMID 10777571. doi:10.1074/jbc.275.17.12752.
Further reading
- Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. PMID 9653655. doi:10.1006/geno.1998.5289.
- Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J. Cell Biol. 149 (1): 67–80. PMC 2175106 . PMID 10747088. doi:10.1083/jcb.149.1.67.
- Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. PMID 10777571. doi:10.1074/jbc.275.17.12752.
- Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. PMID 10814529. doi:10.1006/bbrc.2000.2700.
- Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. PMID 12042876. doi:10.1038/nsb808.
- Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ (2002). "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin". Structure. 10 (8): 1139–48. PMID 12176391. doi:10.1016/S0969-2126(02)00801-8.
- Mills IG, Praefcke GJ, Vallis Y, Peter BJ, Olesen LE, Gallop JL, Butler PJ, Evans PR, McMahon HT (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. PMC 2172650 . PMID 12538641. doi:10.1083/jcb.200208023.
- Lui WW, Collins BM, Hirst J, Motley A, Millar C, Schu P, Owen DJ, Robinson MS (2003). "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin". Mol. Biol. Cell. 14 (6): 2385–98. PMC 194887 . PMID 12808037. doi:10.1091/mbc.E02-11-0735.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
- Hirst J, Borner GH, Harbour M, Robinson MS (2005). "The aftiphilin/p200/gamma-synergin complex". Mol. Biol. Cell. 16 (5): 2554–65. PMC 1087257 . PMID 15758025. doi:10.1091/mbc.E04-12-1077.
- Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G (2005). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Mol. Biol. Cell. 16 (11): 5356–72. PMC 1266432 . PMID 16162817. doi:10.1091/mbc.E05-07-0626.