ANXA8L2

ANXA8L1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1W3W,%%s1W45, 1W3W

Identifiers

Aliases

ANXA8L1, ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1

External IDs

MGI: 1201374 HomoloGene: 20393 GeneCards: ANXA8L1

Gene ontology
Molecular function	• calcium-dependent phospholipid binding • metal ion binding • calcium ion binding • actin filament binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• extracellular exosome • cytosol • plasma membrane • late endosome membrane
Biological process	• hemostasis • endosomal transport • negative regulation of phospholipase A2 activity • blood coagulation • negative regulation of serine-type endopeptidase activity • endosome organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


728113


11752

Ensembl


ENSG00000264230


ENSMUSG00000021950

UniProt


Q5VT79 P13928


O35640

RefSeq (mRNA)


n/a


NM_001281845 NM_013473

RefSeq (protein)


NP_001092315.2 NP_001265853.1 NP_001035173 NP_001258631 NP_001258632


NP_001268774 NP_038501

Location (UCSC)

n/a

Chr 14: 34.09 – 34.1 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[3]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[3]

References

External links

Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser.
Human ANXA8L1 genome location and ANXA8L1 gene details page in the UCSC Genome Browser.

Gerke V, Moss SE (2002). "Annexins: from structure to function.". Physiol. Rev. 82 (2): 331–71. PMID 11917092. doi:10.1152/physrev.00030.2001.
Gerke V, Creutz CE, Moss SE (2005). "Annexins: linking Ca2+ signalling to membrane dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 449–61. PMID 15928709. doi:10.1038/nrm1661.
Chang KS, Wang G, Freireich EJ, et al. (1992). "Specific expression of the annexin VIII gene in acute promyelocytic leukemia.". Blood. 79 (7): 1802–10. PMID 1313714.
Chambers JA, Gardner E, Hauptmann R, et al. (1993). "TaqI polymorphisms at the annexin VIII locus (ANX8).". Hum. Mol. Genet. 1 (7): 550. PMID 1364010. doi:10.1093/hmg/1.7.550.
Hauptmann R, Maurer-Fogy I, Krystek E, et al. (1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha.". Eur. J. Biochem. 185 (1): 63–71. PMID 2530088. doi:10.1111/j.1432-1033.1989.tb15082.x.
Sarkar A, Yang P, Fan YH, et al. (1994). "Regulation of the expression of annexin VIII in acute promyelocytic leukemia.". Blood. 84 (1): 279–86. PMID 8018923.
Reutelingsperger CP, van Heerde W, Hauptmann R, et al. (1994). "Differential tissue expression of Annexin VIII in human.". FEBS Lett. 349 (1): 120–4. PMID 8045287. doi:10.1016/0014-5793(94)00559-1.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature. 429 (6990): 375–81. PMID 15164054. doi:10.1038/nature02462.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Stein T, Price KN, Morris JS, et al. (2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.". Clin. Cancer Res. 11 (19 Pt 1): 6872–9. PMID 16203777. doi:10.1158/1078-0432.CCR-05-0547.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Goebeler V, Ruhe D, Gerke V, Rescher U (2006). "Annexin A8 displays unique phospholipid and F-actin binding properties.". FEBS Lett. 580 (10): 2430–4. PMID 16638567. doi:10.1016/j.febslet.2006.03.076.

PDB gallery

1w3w: THE 2.1 ANGSTROEM RESOLUTION STRUCTURE OF ANNEXIN A8

1w45: THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.

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ANXA8L2

References

External links

Further reading