AMOTL2

AMOTL2

Identifiers

AMOTL2, LCCP, angiomotin like 2

External IDs

MGI: 1929286 HomoloGene: 9420 GeneCards: AMOTL2

Gene ontology
Molecular function	• protein binding • identical protein binding
Cellular component	• recycling endosome • cytosol • endosome • apical plasma membrane • cytoplasmic vesicle • bicellular tight junction
Biological process	• Wnt signaling pathway • hippo signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


51421


56332


ENSG00000114019


ENSMUSG00000032531


Q9Y2J4


Q8K371

RefSeq (mRNA)


NM_001278683 NM_001278685 NM_016201


NM_019764

RefSeq (protein)


NP_001265612 NP_001265614 NP_057285


NP_062738

Location (UCSC)

Chr 3: 134.36 – 134.38 Mb

Chr 9: 102.72 – 102.73 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.^[3]

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.^[3]

References

External links

Human AMOTL2 genome location and AMOTL2 gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032. doi:10.1093/dnares/6.1.63.
Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.". Gene. 298 (1): 69–77. PMID 12406577. doi:10.1016/S0378-1119(02)00928-9.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.