ALYREF

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3ULH

Identifiers

Aliases

ALYREF, ALY, ALY/REF, BEF, REF, THOC4, Aly/REF export factor

External IDs

HomoloGene: 134554 GeneCards: ALYREF

Gene ontology
Molecular function	• protein binding • nucleic acid binding • RNA binding
Cellular component	• cytoplasm • cytosol • nuclear speck • catalytic step 2 spliceosome • membrane • transcription export complex • exon-exon junction complex • spliceosomal complex • extracellular exosome • nuclear chromosome, telomeric region • nucleus • nucleoplasm
Biological process	• regulation of DNA recombination • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • mRNA processing • viral mRNA export from host cell nucleus • mRNA export from nucleus • positive regulation of DNA-templated transcription, elongation • osteoblast differentiation • replication fork processing • viral process • mRNA 3'-end processing • RNA splicing • RNA export from nucleus • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10189


n/a

Ensembl


ENSG00000183684


n/a

UniProt


Q86V81


n/a

RefSeq (mRNA)


NM_005782


n/a

RefSeq (protein)


NP_005773


n/a

Location (UCSC)

Chr 17: 81.89 – 81.89 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene.^[2]^[3]

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.^[4]

References

↑ "Human PubMed Reference:".
↑ Muravenko OV, Gizatullin RZ, Al-Amin AN, Protopopov AI, Kashuba VI, Zelenin AV, Zabarovsky ER (Jan 2001). "Human ALY/BEF gene Map position 17q25.3". Chromosome Res. 8 (6): 562. PMID 11032328. doi:10.1023/A:1009236126053.
↑ "Entrez Gene: ALYREF Aly/REF export factor".
↑ "Entrez Gene: THOC4 THO complex 4".

Bruhn L, Munnerlyn A, Grosschedl R (1997). "ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.". Genes Dev. 11 (5): 640–53. PMID 9119228. doi:10.1101/gad.11.5.640.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. PMID 9731529. doi:10.1038/1700.
Wichmann I, Garcia-Lozano JR, Respaldiza N, et al. (1999). "Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.". Hum. Immunol. 60 (1): 57–62. PMID 9952027. doi:10.1016/S0198-8859(98)00085-8.
Virbasius CM, Wagner S, Green MR (1999). "A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins.". Mol. Cell. 4 (2): 219–28. PMID 10488337. doi:10.1016/S1097-2765(00)80369-X.
Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2001). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.". EMBO J. 19 (24): 6860–9. PMC 305905 . PMID 11118221. doi:10.1093/emboj/19.24.6860.
Kim VN, Kataoka N, Dreyfuss G (2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.". Science. 293 (5536): 1832–6. PMID 11546873. doi:10.1126/science.1062829.
Luo ML, Zhou Z, Magni K, et al. (2001). "Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly.". Nature. 413 (6856): 644–7. PMID 11675789. doi:10.1038/35098106.
Kataoka N, Diem MD, Kim VN, et al. (2002). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.". EMBO J. 20 (22): 6424–33. PMC 125744 . PMID 11707413. doi:10.1093/emboj/20.22.6424.
Strässer K, Masuda S, Mason P, et al. (2002). "TREX is a conserved complex coupling transcription with messenger RNA export.". Nature. 417 (6886): 304–8. PMID 11979277. doi:10.1038/nature746.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA. 8 (4): 426–39. PMC 1370266 . PMID 11991638. doi:10.1017/S1355838202021088.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231–45. PMC 186633 . PMID 12176931. doi:10.1101/gr.473902.
Chen IH, Sciabica KS, Sandri-Goldin RM (2002). "ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.". J. Virol. 76 (24): 12877–89. PMC 136725 . PMID 12438613. doi:10.1128/JVI.76.24.12877-12889.2002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
McCracken S, Longman D, Johnstone IL, et al. (2004). "An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.". J. Biol. Chem. 278 (45): 44153–60. PMID 12944400. doi:10.1074/jbc.M306856200.
Pryor A, Tung L, Yang Z, et al. (2004). "Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.". Nucleic Acids Res. 32 (6): 1857–65. PMC 390356 . PMID 15047853. doi:10.1093/nar/gkh347.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.". Nat. Methods. 1 (2): 119–26. PMID 15782174. doi:10.1038/nmeth715.
Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing.". Genes Dev. 19 (13): 1512–7. PMC 1172058 . PMID 15998806. doi:10.1101/gad.1302205.
Mertz JA, Kobayashi R, Dudley JP (2007). "ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.". J. Virol. 81 (7): 3503–13. PMC 1866045 . PMID 17229714. doi:10.1128/JVI.02253-06.
Quaresma AJ, Sievert R, Nickerson JA (2013). "Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.". Mol. Biol. Cell. 24 (8): 1208–21. PMC 3623641 . PMID 23427269. doi:10.1091/mbc.E12-06-0450.

External links

ALYREF human gene location in the UCSC Genome Browser.
ALYREF human gene details in the UCSC Genome Browser.

PDB gallery

1no8: SOLUTION STRUCTURE OF THE NUCLEAR FACTOR ALY RBD DOMAIN

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ALYREF

References

Further reading

External links