ALPK1

Identifiers

ALPK1, 8430410J10Rik, LAK, alpha kinase 1

External IDs

MGI: 1918731 HomoloGene: 11849 GeneCards: ALPK1

Gene ontology
Molecular function	• transferase activity • ATP binding • kinase activity • protein serine/threonine kinase activity
Cellular component	• cytoplasm
Biological process	• protein phosphorylation • phosphorylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


80216


71481

Ensembl


ENSG00000073331


ENSMUSG00000028028

UniProt


Q96QP1


Q9CXB8

RefSeq (mRNA)


NM_001102406 NM_001253884 NM_025144


NM_027808

RefSeq (protein)


NP_001095876 NP_001240813 NP_079420


n/a

Location (UCSC)

Chr 4: 112.29 – 112.44 Mb

Chr 3: 127.67 – 127.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.^[3]^[4]^[5]

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ryazanov AG, Pavur KS, Dorovkov MV (Mar 1999). "Alpha-kinases: a new class of protein kinases with a novel catalytic domain". Curr Biol. 9 (2): R43–5. PMID 10021370. doi:10.1016/S0960-9822(99)80006-2.
↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331. doi:10.1093/dnares/7.2.143.
1 2 "Entrez Gene: ALPK1 alpha-kinase 1".

External links

Human ALPK1 genome location and ALPK1 gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954. doi:10.1093/dnares/9.3.99.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMC 16267 . PMID 10737800. doi:10.1073/pnas.97.7.3491.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. PMID 15221005. doi:10.1038/sj.onc.1207782.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Heine M, Cramm-Behrens CI, Ansari A, et al. (2005). "Alpha-kinase 1, a new component in apical protein transport". J. Biol. Chem. 280 (27): 25637–43. PMID 15883161. doi:10.1074/jbc.M502265200.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.

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ALPK1

References

External links

Further reading