ALPI

Identifiers

ALPI, IAP, alkaline phosphatase, intestinal

External IDs

MGI: 87984 HomoloGene: 134333 GeneCards: ALPI

Gene ontology
Molecular function	• protease binding • phosphatase activity • zinc ion binding • protein binding • catalytic activity • hydrolase activity • magnesium ion binding • metal ion binding • alkaline phosphatase activity
Cellular component	• integral component of membrane • anchored component of membrane • membrane • extracellular region • plasma membrane
Biological process	• metabolic process • dephosphorylation • C-terminal protein lipidation • phosphatidic acid biosynthetic process • digestion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


248


11648

Ensembl


ENSG00000163295


ENSMUSG00000036500

UniProt


P09923


P24822

RefSeq (mRNA)


NM_001631


NM_007432

RefSeq (protein)


NP_001622


n/a

Location (UCSC)

Chr 2: 232.46 – 232.46 Mb

Chr 1: 87.12 – 87.13 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. PMC 304282 . PMID 3468508. doi:10.1073/pnas.84.3.695.
↑ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. PMC 304401 . PMID 3469665. doi:10.1073/pnas.84.5.1234.

External links

Human ALPI genome location and ALPI gene details page in the UCSC Genome Browser.

Hirasaka K, Tokuoka K, Nakao R, et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells.". J Physiol Sci. 58 (2): 105–11. PMID 18307834. doi:10.2170/physiolsci.RP013007.
Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433–41. PMID 12660142. doi:10.1152/ajpgi.00466.2002.
Wada A, Wang AP, Isomoto H, et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.". Int. J. Med. Microbiol. 294 (7): 427–35. PMID 15715171. doi:10.1016/j.ijmm.2004.09.012.
Nakano T, Inoue I, Alpers DH, et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207–14. PMID 19407215. doi:10.1152/ajpgi.90590.2008.
Malo MS, Zhang W, Alkhoury F, et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.". Mol. Endocrinol. 18 (8): 1941–62. PMID 15143152. doi:10.1210/me.2003-0351.
Rump A, Kasper G, Hayes C, et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.". Genomics. 73 (1): 50–5. PMID 11352565. doi:10.1006/geno.2000.6504.
Nauli AM, Zheng S, Yang Q, et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation.". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583–7. PMID 12466148. doi:10.1152/ajpgi.00482.2002.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. PMID 15774940. doi:10.1152/ajpgi.00037.2005.
Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.". Semin. Oncol. 29 (6 Suppl 19): 14–21. PMID 12577238. doi:10.1053/sonc.2002.37356.
Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.". Pathol. Res. Pract. 203 (6): 485–7. PMID 17498884. doi:10.1016/j.prp.2007.02.003.
Hinnebusch BF, Siddique A, Henderson JW, et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. PMID 12919939. doi:10.1152/ajpgi.00203.2003.
Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases.". J. Biol. Chem. 277 (51): 49808–14. PMID 12372831. doi:10.1074/jbc.M207394200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Goldberg RF, Austen WG, Zhang X, et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551–6. PMC 2265168 . PMID 18292227. doi:10.1073/pnas.0712140105.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220–6. PMID 15831710. doi:10.1152/ajpgi.00449.2004.
Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.". EMBO J. 25 (24): 5670–82. PMC 1698904 . PMID 17139249. doi:10.1038/sj.emboj.7601459.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4:
Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)

3.1.11-16:
Exonuclease

Exodeoxyribonuclease	RecBCD
Exoribonuclease	Oligonucleotidase

3.1.21-31:
Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease
Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex
either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

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ALPI

References

External links

Further reading