ALDH3B2

Identifiers

ALDH3B2, ALDH8, aldehyde dehydrogenase 3 family member B2

External IDs

Gene ontology
Molecular function	• 3-chloroallyl aldehyde dehydrogenase activity • oxidoreductase activity • aldehyde dehydrogenase [NAD(P)+ activity]
Cellular component	• lipid droplet
Biological process	• ethanol catabolic process • metabolic process • alcohol metabolic process • oxidation-reduction process • lipid metabolic process • sphingolipid biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


222


n/a

Ensembl


ENSG00000132746


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UniProt


P48448


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RefSeq (mRNA)


NM_000695 NM_001031615


n/a

RefSeq (protein)


NP_000686 NP_001026786


n/a

Location (UCSC)

Chr 11: 67.66 – 67.68 Mb

n/a

PubMed search

^[1]

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Wikidata

View/Edit Human

Aldehyde dehydrogenase family 3 member B2 is an enzyme that in humans is encoded by the ALDH3B2 gene.^[2]^[3]^[4]

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.^[4]

References

↑ "Human PubMed Reference:".
↑ Hsu LC, Chang WC (Dec 1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family". Gene. 174 (2): 319–22. PMID 8890755. doi:10.1016/0378-1119(96)00087-X.
↑ Hsu LC, Chang WC, Yoshida A (Jun 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. PMID 9161417. doi:10.1016/S0378-1119(96)00839-6.
1 2 "Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2".

External links

Human ALDH3B2 genome location and ALDH3B2 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMC 16267 . PMID 10737800. doi:10.1073/pnas.97.7.3491.
Hsu LC, Chang WC, Lin SW, Yoshida A (1995). "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes". Adv. Exp. Med. Biol. 372: 159–68. PMID 7484374. doi:10.1007/978-1-4615-1965-2_21.

Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2 (mitochondrial)	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

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ALDH3B2

References

External links

Further reading