ADH1C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1HT0, 1U3W

Identifiers

Aliases

ADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide

External IDs

MGI: 87921 HomoloGene: 73888 GeneCards: ADH1C

Gene ontology
Molecular function	• oxidoreductase activity • zinc ion binding • alcohol dehydrogenase (NAD) activity • metal ion binding • retinol dehydrogenase activity • alcohol dehydrogenase activity, zinc-dependent
Cellular component	• cytoplasm • nucleoplasm • cytosol • plasma membrane
Biological process	• oxidation-reduction process • ethanol oxidation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


126


11522

Ensembl


ENSG00000248144


ENSMUSG00000074207

UniProt


P00326


P00329

RefSeq (mRNA)


NM_000669


NM_007409

RefSeq (protein)


NP_000660


NP_031435

Location (UCSC)

Chr 4: 99.34 – 99.35 Mb

Chr 3: 138.26 – 138.29 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.^[3]

Function

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Advances in Human Genetics. 15: 249–90. PMID 3006456. doi:10.1007/978-1-4615-8356-1_5.
↑ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".

External links

Human ADH1C genome location and ADH1C gene details page in the UCSC Genome Browser.

Seitz HK, Meier P (Jun 2007). "The role of acetaldehyde in upper digestive tract cancer in alcoholics". Translational Research. 149 (6): 293–7. PMID 17543846. doi:10.1016/j.trsl.2006.12.002.
Lange LG, Sytkowski AJ, Vallee BL (Oct 1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. PMID 9982. doi:10.1021/bi00666a023.
Yokoyama S, Matsuo Y, Rajasekharan S, Yokoyama R (Apr 1992). "Molecular structure of the human alcohol dehydrogenase 3 gene". Idengaku Zasshi. 67 (2): 167–71. PMID 1524834. doi:10.1266/jjg.67.167.
Hurley TD, Bosron WF, Hamilton JA, Amzel LM (Sep 1991). "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions". Proceedings of the National Academy of Sciences of the United States of America. 88 (18): 8149–53. PMC 52464 . PMID 1896463. doi:10.1073/pnas.88.18.8149.
Stewart MJ, McBride MS, Winter LA, Duester G (Jun 1990). "Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box". Gene. 90 (2): 271–9. PMID 2169444. doi:10.1016/0378-1119(90)90190-3.
Yasunami M, Kikuchi I, Sarapata D, Yoshida A (Jun 1990). "The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome". Genomics. 7 (2): 152–8. PMID 2347582. doi:10.1016/0888-7543(90)90535-3.
Tsukahara M, Yoshida A (Feb 1989). "Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization". Genomics. 4 (2): 218–20. PMID 2737681. doi:10.1016/0888-7543(89)90304-2.
Ikuta T, Szeto S, Yoshida A (Feb 1986). "Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence". Proceedings of the National Academy of Sciences of the United States of America. 83 (3): 634–8. PMC 322918 . PMID 2935875. doi:10.1073/pnas.83.3.634.
Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (Apr 1988). "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification". Genomics. 2 (3): 209–14. PMID 3397059. doi:10.1016/0888-7543(88)90004-3.
Höög JO, Hedén LO, Larsson K, Jörnvall H, von Bahr-Lindström H (Sep 1986). "The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties". European Journal of Biochemistry / FEBS. 159 (2): 215–8. PMID 3758060. doi:10.1111/j.1432-1033.1986.tb09855.x.
Bühler R, Hempel J, Kaiser R, de Zalenski C, von Wartburg JP, Jörnvall H (Dec 1984). "Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain". European Journal of Biochemistry / FEBS. 145 (3): 447–53. PMID 6391921. doi:10.1111/j.1432-1033.1984.tb08575.x.
Cheung B, Anderson JK, Holmes RS, Beacham IR (Feb 1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcoholism: Clinical and Experimental Research. 19 (1): 185–6. PMID 7771649. doi:10.1111/j.1530-0277.1995.tb01490.x.
Hurley TD, Bosron WF, Stone CL, Amzel LM (Jun 1994). "Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences". Journal of Molecular Biology. 239 (3): 415–29. PMID 8201622. doi:10.1006/jmbi.1994.1382.
Cheung C, Smith CK, Hoog JO, Hotchkiss SA (Jul 1999). "Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin". Biochemical and Biophysical Research Communications. 261 (1): 100–7. PMID 10405330. doi:10.1006/bbrc.1999.0943.
Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H (Aug 1999). "Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family". Biochemical Pharmacology. 58 (3): 389–95. PMID 10424757. doi:10.1016/S0006-2952(99)00065-9.
Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD (Apr 2001). "Three-dimensional structures of the three human class I alcohol dehydrogenases". Protein Science. 10 (4): 697–706. PMC 2373965 . PMID 11274460. doi:10.1110/ps.45001.
Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK (Dec 2002). "A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans". Alcoholism: Clinical and Experimental Research. 26 (12): 1759–63. PMID 12500098. doi:10.1097/01.ALC.0000042013.13899.75.

PDB gallery

1deh: CRYSTALLIZATION OF HUMAN BETA1 ALCOHOL DEHYDROGENASE (15 MG/ML) IN 50 MM SODIUM PHOSPHATE (PH 7.5), 2.0 MM NAD+ AND 1 MM 4-IODOPYRAZOLE AT 25 OC, 13% (W/V) PEG 8000
1hdx: THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
1hdy: THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
1hdz: THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
1hso: HUMAN ALPHA ALCOHOL DEHYDROGENASE (ADH1A)
1hsz: HUMAN BETA-1 ALCOHOL DEHYDROGENASE (ADH1B*1)
1ht0: HUMAN GAMMA-2 ALCOHOL DEHYDROGENSE
1htb: CRYSTALLIZATION OF HUMAN BETA3 ALCOHOL DEHYDROGENASE (10 MG/ML) IN 100 MM SODIUM PHOSPHATE (PH 7.5), 7.5 MM NAD+ AND 1 MM 4-IODOPYRAZOLE AT 25 C
1u3t: Crystal Structure of Human Alcohol Dehydrogenase Alpha-Alpha Isoform Complexed with N-Cyclopentyl-N-Cyclobutylformamide Determined to 2.5 Angstrom Resolution
1u3u: Crystal Structure of Human Alcohol Dehydrogenase Beta-1-Beta-1 Isoform Complexed with N-Benzylformamide Determined to 1.6 Angstrom Resolution
1u3v: Crystal Structure of Human Alcohol Dehydrogenase Beta-1-Beta-1 Isoform Complexed with N-Heptylformamide Determined to 1.65 Angstrom Resolution
1u3w: Crystal Structure of Human Alcohol Dehydrogenase Gamma-2-Gamma-2 Isoform Complexed with N-1-Methylheptylformamide Determined to 1.45 Angstrom Resolution
3hud: THE STRUCTURE OF HUMAN BETA 1 BETA 1 ALCOHOL DEHYDROGENASE: CATALYTIC EFFECTS OF NON-ACTIVE-SITE SUBSTITUTIONS

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ADH1C

Function

References

External links

Further reading