ACTR1B
| ACTR1B | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | ACTR1B, ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B | ||||||||||||||||
| External IDs | MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 2: 97.66 – 97.66 Mb | Chr 1: 36.7 – 36.71 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[3][4][5]
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. PMC 301159
. PMID 7696711. doi:10.1091/mbc.5.12.1301. - ↑ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. PMID 10343100. doi:10.1159/000015211.
- 1 2 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".
Further reading
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell. 14 (7): 2645–54. PMC 165665 . PMID 12857853. doi:10.1091/mbc.E03-01-0049.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
- Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. PMID 1538749. doi:10.1038/355632a0.
External links
- ACTR1B human gene location in the UCSC Genome Browser.
- ACTR1B human gene details in the UCSC Genome Browser.
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