ACE inhibitor and thiazide combination
An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.
Examples
- Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
| Combination of | |
|---|---|
| Quinapril | Angiotensin converting enzyme inhibitor |
| Hydrochlorothiazide | Thiazide diuretic |
| Clinical data | |
| Trade names | Accuretic |
| AHFS/Drugs.com | Multum Consumer Information |
| Pregnancy category |
|
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| ChemSpider | |
| KEGG | |
| Combination of | |
|---|---|
| Lisinopril | ACE inhibitor |
| Hydrochlorothiazide | Thiazide diuretic |
| Clinical data | |
| MedlinePlus | a601070 |
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| KEGG | |
| (verify) | |
- Lisinopril/hydrochlorothiazide is marketed as Prinzide[2] by Merck & Co., Zestoretic[3] by AstraZeneca, and many others.
Fosinopril/hydrochlorothiazide
| Combination of | |
|---|---|
| Fosinopril | Angiotensin converting enzyme inhibitor |
| Hydrochlorothiazide | Thiazide diuretic |
| Clinical data | |
| Trade names | Monopril HCT |
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).[4]
FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."[5]
See also
- Perindopril/indapamide, a combination of an ACE inhibitor and a thiazide-like diuretic
References
- ↑ Accuretic Multum Consumer Information
- ↑ Prinzide at drugs.com
- ↑ Zestoretic at drugs.com
- ↑ "fosinopril/hydrochlorothiazide (Rx) - Contraindications & Cautions". Medscape. Retrieved 13 December 2013.
- ↑ "Monopril HCT (fosinopril/hydrochlorothiazide) 20/12.5mg and 10/12.5mg Tablets February 2009". FDA.
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