ACBD3

ACBD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
External IDsMGI: 2181074 HomoloGene: 11227 GeneCards: ACBD3
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64746

170760

Ensembl

ENSG00000182827

ENSMUSG00000026499

UniProt

Q9H3P7

Q8BMP6

RefSeq (mRNA)

NM_022735

NM_133225

RefSeq (protein)

NP_073572
NP_073572.2

NP_573488

Location (UCSC)Chr 1: 226.14 – 226.19 MbChr 1: 180.73 – 180.75 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.[3]

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.[3]

Interactions

ACBD3 has been shown to interact with GOLGB1.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
  4. ↑ Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. PMID 11590181. doi:10.1074/jbc.M108961200.

Further reading

  • Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.". J. Biol. Chem. 276 (48): 45298–306. PMID 11590181. doi:10.1074/jbc.M108961200. 
  • Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.". Mol. Endocrinol. 15 (12): 2211–28. PMID 11731621. doi:10.1210/me.15.12.2211. 
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810. 
  • Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. PMID 12692076. doi:10.1096/fj.02-1066fje. 
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. PMC 442148 Freely accessible. PMID 15231748. doi:10.1101/gr.2334104. 
  • Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. PMID 16870622. doi:10.1074/jbc.M603276200. 
  • Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. PMID 17711851. doi:10.1074/jbc.M705794200. 
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.