A-412,997
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Formula | C19H23N3O |
Molar mass | 309.405 g/mol |
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A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269.[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.[2][3] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.[4]
References
- ↑ Moreland, RB; Patel, M; Hsieh, GC; Wetter, JM; Marsh, K; Brioni, JD (2005). "A-412997 is a selective dopamine D4 receptor agonist in rats". Pharmacology, Biochemistry, and Behavior. 82 (1): 140–7. PMID 16153699. doi:10.1016/j.pbb.2005.08.001.
- ↑ Browman, KE; Curzon, P; Pan, JB; Molesky, AL; Komater, VA; Decker, MW; Brioni, JD; Moreland, RB; Fox, GB (2005). "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats". Pharmacology, Biochemistry, and Behavior. 82 (1): 148–55. PMID 16154186. doi:10.1016/j.pbb.2005.08.002.
- ↑ Woolley, Marie L.; Waters, Kerry A.; Reavill, Charlie; Bull, Sharlene; Lacroix, Laurent P.; Martyn, Abbe J.; Hutcheson, Daniel M.; Valerio, Enzo; Bate, Simon; Jones, Declan N.C.; Dawson, Lee A. (December 2008). "Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat". Behavioural Pharmacology. 19 (8): 765–76. PMID 19020411. doi:10.1097/FBP.0b013e32831c3b06.
- ↑ Osinski, MA; Uchic, ME; Seifert, T; Shaughnessy, TK; Miller, LN; Nakane, M; Cox, BF; Brioni, JD; Moreland, RB (2005). "Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets". Pharmacology, Biochemistry, and Behavior. 81 (1): 211–9. PMID 15894081. doi:10.1016/j.pbb.2005.03.012.
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