25-Hydroxyvitamin D3 1-alpha-hydroxylase

CYP27B1
Identifiers
AliasesCYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1
External IDsOMIM: 609506 MGI: 1098274 HomoloGene: 37139 GeneCards: CYP27B1
EC number1.14.13.13
Orthologs
SpeciesHumanMouse
Entrez

1594

13115

Ensembl

ENSG00000111012

ENSMUSG00000006724

UniProt

O15528

O35084

RefSeq (mRNA)

NM_000785

NM_010009

RefSeq (protein)

NP_000776

NP_034139

Location (UCSC)Chr 12: 57.76 – 57.77 MbChr 10: 127.05 – 127.05 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

25-Hydroxyvitamin D3 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.[3][4][5]

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells,[6] and bone (osteoblasts).[7] The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):[8]

calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 calcitriol + 2 oxidized adrenodoxin + H2O
calcidiol 1-monooxygenase
Identifiers
EC number 1.14.15.18
CAS number 9081-36-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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VitaminDSynthesis_WP1531 Go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article go to article go to article go to article Go to article go to article

|{{{bSize}}}px|alt=Vitamin D Synthesis Pathway (view / edit)]]

Vitamin D Synthesis Pathway (view / edit)

  1. ↑ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: cytochrome P450".
  4. ↑ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science. 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.
  5. ↑ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochemical and Biophysical Research Communications. 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.
  6. ↑ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC (Mar 2007). "DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27" (PDF). Nature Immunology. 8 (3): 285–93. PMID 17259988. doi:10.1038/ni1433.
  7. ↑ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ (Oct 2010). "Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption". Endocrinology. 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334.
  8. ↑ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF (Dec 1972). "25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties". The Journal of Biological Chemistry. 247 (23): 7528–32. PMID 4404596.

Further reading

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