Arrestin beta 2

ARRB2
Identifiers
Aliases	ARRB2, ARB2, ARR2, BARR2, Arrestin beta 2
External IDs	MGI: 99474 HomoloGene: 3183 GeneCards: ARRB2
Gene ontology Molecular function • type 2A serotonin receptor binding • protein domain specific binding • type 1 angiotensin receptor binding • platelet activating factor receptor binding • protein complex binding • alpha-1B adrenergic receptor binding • 14-3-3 protein binding • protein kinase B binding • mitogen-activated protein kinase binding • follicle-stimulating hormone receptor binding • protein binding • enzyme binding • angiotensin receptor binding • protein complex scaffold activity • D1 dopamine receptor binding • receptor binding • G-protein coupled receptor binding • ubiquitin protein ligase binding • alpha-1A adrenergic receptor binding Cellular component • cytoplasm • cytosol • postsynaptic membrane • postsynaptic density of dendrite • membrane • plasma membrane • endocytic vesicle • dendritic spine • intracellular • basolateral plasma membrane • clathrin-coated pit • cytoplasmic vesicle • nucleus • intracellular membrane-bounded organelle Biological process • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of calcium ion transport • regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • negative regulation of interleukin-1 beta production • negative regulation of protein kinase B signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein kinase B signaling • positive regulation of protein phosphorylation • endocytosis • regulation of G-protein coupled receptor protein signaling pathway • positive regulation of receptor internalization • chemical synaptic transmission, postsynaptic • negative regulation of release of cytochrome c from mitochondria • negative regulation of interleukin-6 production • receptor internalization • transcription from RNA polymerase II promoter • positive regulation of peptidyl-serine phosphorylation • detection of temperature stimulus involved in sensory perception of pain • follicle-stimulating hormone signaling pathway • platelet activation • dopamine receptor signaling pathway • negative regulation of protein ubiquitination • brain development • negative regulation of GTPase activity • negative regulation of toll-like receptor signaling pathway • protein ubiquitination • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell chemotaxis • protein transport • negative regulation of natural killer cell mediated cytotoxicity • regulation of androgen receptor signaling pathway • positive regulation of synaptic transmission, dopaminergic • negative regulation of tumor necrosis factor production • negative regulation of signal transduction • positive regulation of protein ubiquitination • transforming growth factor beta receptor signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of smooth muscle cell apoptotic process • desensitization of G-protein coupled receptor protein signaling pathway by arrestin • signal transduction • adult walking behavior • negative regulation of interleukin-12 production • Wnt signaling pathway, planar cell polarity pathway • negative regulation of protein phosphorylation • G-protein coupled receptor internalization • positive regulation of gene expression • protein deubiquitination • membrane organization • positive regulation of cardiac muscle cell differentiation • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	409	216869
Ensembl	ENSG00000141480	ENSMUSG00000060216
UniProt	P32121	Q91YI4
RefSeq (mRNA)	NM_001257328 NM_001257329 NM_001257330 NM_001257331 NM_004313 NM_199004 NM_001330064	NM_001271358 NM_001271359 NM_001271360 NM_145429
RefSeq (protein)	NP_001244257 NP_001244258 NP_001244259 NP_001244260 NP_001316993 NP_004304 NP_945355	NP_001258287 NP_001258288 NP_001258289 NP_663404
Location (UCSC)	Chr 17: 4.71 – 4.72 Mb	Chr 11: 70.43 – 70.44 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,^[3][4][5] as well as having signalling roles in their own right.^{[6][7][8][9][10]} Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[11]

The protein may interact with the agonist DOI in 5-HT_2A receptor signaling.^[12][13]

Interactions

Arrestin beta 2 has been shown to interact with

• AP2B1,^[14][15]
• PSCD2,^[16]
• Mdm2,^[17][18][19] and
• RALGDS.^[20]

References

Further reading

External links

• Human ARRB2 genome location and ARRB2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.