Zucapsaicin

Zucapsaicin
Systematic (IUPAC) name

(Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Clinical data
Trade names	Civanex
Routes of administration	Topical
Identifiers
CAS Number	25775-90-0
ATC code	M02AB02
PubChem	CID 1548942
ChemSpider	1265956
UNII	15OX67P384
Synonyms	Civamide; (Z)-Capsaicin; cis-Capsaicin
Chemical data
Formula	C₁₈H₂₇NO₃
Molar mass	305.41188 g/mol
SMILES Oc1ccc(cc1OC)CNC(CCCC\C=C/C(C)C)=O
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6- Key:YKPUWZUDDOIDPM-VURMDHGXSA-N

Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).^[1]

Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis.^[2]

References

↑ Winston Pharmaceuticals website http://www.winstonlabs.com/productdevelopment/civamide.asp
↑ Zucapsaicin information from the National Library of Medicine http://druginfo.nlm.nih.gov/drugportal

Topical products for joint and muscular pain (M02)

Anti-inflammatory
preparations,
non-steroids

Pyrazolidines	Phenylbutazone Mofebutazone Clofezone Oxyphenbutazone

Acetic acid derivatives	Tolmetin Diclofenac Fentiazac

Other	Benzydamine Etofenamate Piroxicam Felbinac Bufexamac Ketoprofen Bendazac Naproxen Ibuprofen Feprazone Niflumic acid Meclofenamic acid Flurbiprofen Suxibuzone Indometacin Nifenazone

Capsaicin derivatives

Zucapsaicin

Other

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