Zinc finger FYVE domain-containing protein 9

Zinc finger, FYVE domain containing 9

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1DEV, 1MK2

Identifiers

Symbols

ZFYVE9 ; MADHIP; NSP; SARA; SMADIP

External IDs

OMIM: 603755 MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9 Gene

Gene ontology
Molecular function	• protein binding • 1-phosphatidylinositol binding • serine-type peptidase activity • metal ion binding
Cellular component	• cytoplasm • early endosome • early endosome membrane
Biological process	• endocytosis • transforming growth factor beta receptor signaling pathway • SMAD protein complex assembly • SMAD protein import into nucleus • negative regulation of transforming growth factor beta receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
52.61 – 52.81 Mb

Chr 4:
108.64 – 108.78 Mb

PubMed search

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.^[1] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.^[2] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

References

↑ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696.
↑ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.

Cell signaling: TGF beta signaling pathway

TGF beta superfamily of ligands

TGF beta family	TGF-β1 TGF-β2 TGF-β3

Bone morphogenetic proteins	BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8a BMP8b BMP10 BMP15

Growth differentiation factors	GDF1 GDF2 GDF3 GDF5 GDF6 GDF7 Myostatin/GDF8 GDF9 GDF10 GDF11 GDF15

Other	Activin and inhibin Anti-müllerian hormone Nodal

TGF beta receptors
(Activin, BMP)

TGFBR1:	Activin type 1 receptors ACVR1 ACVR1B ACVR1C ACVRL1 BMPR1 BMPR1A BMPR1B

TGFBR2:	Activin type 2 receptors ACVR2A ACVR2B AMHR2 BMPR2

TGFBR3:	betaglycan

Transducers/SMAD

Ligand inhibitors

Coreceptors

BAMBI
Cripto

Other

SARA

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