ZNF703

zinc finger protein 703
Identifiers
Symbol ZNF703
Entrez 80139
HUGO 25883
RefSeq NM_025069
Other data
Locus Chr. 8 p12

ZNF703[1] is a gene which has been linked with the development of breast cancers.[2][3][4]

Following research by scientists at Cancer Research UK, it was the first oncogene discovery in the past five years.[3]

ZNF703 is a part of 8p12 telomeric amplicon that is associated with Luminal B breast cancer. Recently, ZNF703 is identified as the driver of 8p12 locus amplication. [5]

References

  1. ↑ http://www.ebi.ac.uk/gxa/gene?gid=Q9H7S9
  2. ↑ Sircoulomb F, Nicolas N, Ferrari A, et al. (February 2011). "ZNF703 gene amplification at 8p12 specifies luminal B breast cancer". EMBO Molecular Medicine 3 (3): 153–166. doi:10.1002/emmm.201100121. PMC 3395112. PMID 21328542.
  3. 1 2 "BBC News - Key breast cancer 'driver' gene found". 2011-02-18. Retrieved 2011-02-18.
  4. ↑ Kwek SS, Roy R, Zhou H, et al. (April 2009). "Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis". Oncogene 28 (17): 1892–903. doi:10.1038/onc.2009.34. PMC 2722962. PMID 19330026.
  5. ↑ Holland, Daniel (Feb 2011). "ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium". EMBO Molecular Medicine 3: 167–80. doi:10.1002/emmm.201100122. PMC 3395113. PMID 21337521. Retrieved 2011-02-18.


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