ZNF365
| Zinc finger protein 365 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | ZNF365 ; Su48; UAN; ZNF365D | ||||||||||
| External IDs | OMIM: 607818 MGI: 2143676 HomoloGene: 8975 GeneCards: ZNF365 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 22891 | 216049 | |||||||||
| Ensembl | ENSG00000138311 | ENSMUSG00000037855 | |||||||||
| UniProt | Q70YC4 | Q8BG89 | |||||||||
| RefSeq (mRNA) | NM_014951 | NM_178679 | |||||||||
| RefSeq (protein) | NP_055766 | NP_848794 | |||||||||
| Location (UCSC) |
Chr 10: 62.37 – 62.67 Mb |
Chr 10: 67.89 – 67.91 Mb | |||||||||
| PubMed search | |||||||||||
Protein ZNF365 is a protein that in humans is encoded by the ZNF365 gene.[1][2][3]
Model organisms
Model organisms have been used in the study of ZNF365 function. A conditional knockout mouse line called Zfp365tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10] - in-depth bone and cartilage phenotyping[11]
| Characteristic | Phenotype |
|---|---|
| All data available at.[5][10][11] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Abnormal |
| Insulin | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Influenza Challenge | Normal |
References
- ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ↑ Gianfrancesco F, Esposito T, Ombra MN, Forabosco P, Maninchedda G, Fattorini M, Casula S, Vaccargiu S, Casu G, Cardia F, Deiana I, Melis P, Falchi M, Pirastu M (Jun 2003). "Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate". American Journal of Human Genetics 72 (6): 1479–91. doi:10.1086/375628. PMC 1180308. PMID 12740763.
- ↑ "Entrez Gene: ZNF365 zinc finger protein 365".
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- 1 2 "International Mouse Phenotyping Consortium".
- ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
- 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".
- 1 2 "OBCD Consortium".
Further reading
- Ombra MN, Forabosco P, Casula S, Angius A, Maestrale G, Petretto E, Casu G, Colussi G, Usai E, Melis P, Pirastu M (May 2001). "Identification of a new candidate locus for uric acid nephrolithiasis". American Journal of Human Genetics 68 (5): 1119–29. doi:10.1086/320105. PMC 1226093. PMID 11309680.
- Gianfrancesco F, Esposito T, Casu G, Maninchedda G, Roberto R, Pirastu M (Sep 2004). "Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage". Gene 339: 131–8. doi:10.1016/j.gene.2004.06.030. PMID 15363853.
- Wang Q, Du X, Meinkoth J, Hirohashi Y, Zhang H, Liu Q, Richter M, Greene MI (Apr 2006). "Characterization of Su48, a centrosome protein essential for cell division". Proceedings of the National Academy of Sciences of the United States of America 103 (17): 6512–7. doi:10.1073/pnas.0601682103. PMC 1458915. PMID 16617106.
- Hirohashi Y, Wang Q, Liu Q, Li B, Du X, Zhang H, Furuuchi K, Masuda K, Sato N, Greene MI (Oct 2006). "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation". Oncogene 25 (45): 6048–55. doi:10.1038/sj.onc.1209637. PMID 16682949.
External links
- ZNF365 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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