ZNF202
| Zinc finger protein 202 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ZNF202 ; ZKSCAN10; ZSCAN42 | ||||||||||||
| External IDs | OMIM: 603430 MGI: 1933401 HomoloGene: 68317 GeneCards: ZNF202 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7753 | 80902 | |||||||||||
| Ensembl | ENSG00000166261 | ENSMUSG00000025602 | |||||||||||
| UniProt | O95125 | E9Q2D3 | |||||||||||
| RefSeq (mRNA) | NM_001301779 | NM_030713 | |||||||||||
| RefSeq (protein) | NP_001288708 | NP_109638 | |||||||||||
| Location (UCSC) |
Chr 11: 123.72 – 123.74 Mb |
Chr 9: 40.19 – 40.21 Mb | |||||||||||
| PubMed search | |||||||||||||
Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2]
Clinical significance
Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.
References
- ↑ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
- ↑ "Entrez Gene: ZNF202 zinc finger protein 202".
Further reading
- Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0.
- Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
- Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
- Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
- Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.
External links
- ZNF202 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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