ZFP36L1

ZFP36 ring finger protein-like 1

PDB rendering based on 1rgo.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1W0V, 1W0W

Identifiers

Symbols

ZFP36L1 ; BRF1; Berg36; ERF-1; ERF1; RNF162B; TIS11B; cMG1

External IDs

OMIM: 601064 MGI: 107946 HomoloGene: 31276 GeneCards: ZFP36L1 Gene

Gene ontology
Molecular function	• DNA binding • transcription factor activity, sequence-specific DNA binding • mRNA binding • protein binding • AU-rich element binding • poly(A) RNA binding • metal ion binding
Cellular component	• nucleus • cytosol
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • vasculogenesis • proepicardium development • regulation of transcription, DNA-templated • regulation of translation • apoptotic process • heart development • cell proliferation • gene expression • neural tube development • T cell differentiation in thymus • multicellular organism growth • regulation of mRNA stability • chorio-allantoic fusion • spongiotrophoblast layer development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

677

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
68.79 – 68.8 Mb

Chr 12:
80.11 – 80.11 Mb

PubMed search

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.^[1]^[2]

Function

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.^[2]

Interactions

ZFP36L1 has been shown to interact with MAPK14.^[3]

References

↑ Bustin SA, Nie XF, Barnard RC, Kumar V, Pascall JC, Brown KD, Leigh IM, Williams NS, McKay IA (Aug 1994). "Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes". DNA Cell Biol 13 (5): 449–59. doi:10.1089/dna.1994.13.449. PMID 8024689.
1 2 "Entrez Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1".
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M (August 2010). "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia". Nat. Immunol. 11 (8): 717–24. doi:10.1038/ni.1901. PMC 2953641. PMID 20622884.
Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, Burton GJ, Murphy JJ, Norton JD, Clark AR, Turner M (November 2006). "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression". Dev. Dyn. 235 (11): 3144–55. doi:10.1002/dvdy.20949. PMID 17013884.
Barnard RC, Pascall JC, Brown KD, McKay IA, Williams NS, Bustin SA (July 1993). "Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes". Nucleic Acids Res. 21 (15): 3580. doi:10.1093/nar/21.15.3580. PMC 331466. PMID 8346037.
Maclean KN, See CG, McKay IA, Bustin SA (November 1995). "The human immediate early gene BRF1 maps to chromosome 14q22-q24". Genomics 30 (1): 89–90. doi:10.1006/geno.1995.0014. PMID 8595910.
Ning ZQ, Norton JD, Li J, Murphy JJ (October 1996). "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36". Eur. J. Immunol. 26 (10): 2356–63. doi:10.1002/eji.1830261013. PMID 8898945.
Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H (2003). "Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins". Prog. Nucleic Acid Res. Mol. Biol. 75: 43–68. doi:10.1016/S0079-6603(03)75002-8. PMID 14604009.
Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R (November 2004). "Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells". Biochem. Biophys. Res. Commun. 324 (1): 218–23. doi:10.1016/j.bbrc.2004.09.030. PMID 15465005.
Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, Lamarre J, Feige JJ (November 2004). "Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b". Oncogene 23 (53): 8673–80. doi:10.1038/sj.onc.1207939. PMID 15467755.

PDB gallery

1rgo: Structural Basis for Recognition of the mRNA Class II AU-Rich Element by the Tandem Zinc Finger Domain of TIS11d

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ZFP36L1

Function

Interactions

References

Further reading