XRCC2

X-ray repair complementing defective repair in Chinese hamster cells 2
Identifiers
Symbols XRCC2 ; DKFZp781P0919
External IDs OMIM: 600375 MGI: 1927345 HomoloGene: 3964 GeneCards: XRCC2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7516 57434
Ensembl ENSG00000196584 ENSMUSG00000028933
UniProt O43543 Q9CX47
RefSeq (mRNA) NM_005431 NM_020570
RefSeq (protein) NP_005422 NP_065595
Location (UCSC) Chr 7:
152.64 – 152.68 Mb
Chr 5:
25.69 – 25.71 Mb
PubMed search

DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.[1][2][3]

Function

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.[3]

Interactions

XRCC2 has been shown to interact with RAD51L3,[4][5][6][7] Bloom syndrome protein[5] and RAD51C.[7][8]

References

  1. Jones NJ, Zhao Y, Siciliano MJ, Thompson LH (Apr 1995). "Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis". Genomics 26 (3): 619–22. doi:10.1016/0888-7543(95)80187-Q. PMID 7607692.
  2. Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ (Jun 1999). "The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells". Mutation Research 434 (2): 75–88. doi:10.1016/s0921-8777(99)00010-5. PMID 10422536.
  3. 1 2 "Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2".
  4. Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (Jun 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". The Journal of Biological Chemistry 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
  5. 1 2 Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (Nov 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". The Journal of Biological Chemistry 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.
  6. Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (Jun 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Human Molecular Genetics 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
  7. 1 2 Liu N, Schild D, Thelen MP, Thompson LH (Feb 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Research 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
  8. Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (Mar 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". The Journal of Biological Chemistry 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.

Further reading

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