XRCC2
DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.[1][2][3]
Function
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.[3]
Interactions
XRCC2 has been shown to interact with RAD51L3,[4][5][6][7] Bloom syndrome protein[5] and RAD51C.[7][8]
References
- ↑ Jones NJ, Zhao Y, Siciliano MJ, Thompson LH (Apr 1995). "Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis". Genomics 26 (3): 619–22. doi:10.1016/0888-7543(95)80187-Q. PMID 7607692.
- ↑ Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ (Jun 1999). "The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells". Mutation Research 434 (2): 75–88. doi:10.1016/s0921-8777(99)00010-5. PMID 10422536.
- 1 2 "Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2".
- ↑ Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (Jun 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". The Journal of Biological Chemistry 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
- 1 2 Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (Nov 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". The Journal of Biological Chemistry 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.
- ↑ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (Jun 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Human Molecular Genetics 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
- 1 2 Liu N, Schild D, Thelen MP, Thompson LH (Feb 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Research 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
- ↑ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (Mar 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". The Journal of Biological Chemistry 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
Further reading
- Thacker J, Tambini CE, Simpson PJ, Tsui LC, Scherer SW (Jan 1995). "Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents". Human Molecular Genetics 4 (1): 113–20. doi:10.1093/hmg/4.1.113. PMID 7711722.
- Tambini CE, George AM, Rommens JM, Tsui LC, Scherer SW, Thacker J (Apr 1997). "The XRCC2 DNA repair gene: identification of a positional candidate". Genomics 41 (1): 84–92. doi:10.1006/geno.1997.4636. PMID 9126486.
- Cartwright R, Tambini CE, Simpson PJ, Thacker J (Jul 1998). "The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family". Nucleic Acids Research 26 (13): 3084–9. doi:10.1093/nar/26.13.3084. PMC 147676. PMID 9628903.
- Liu N, Lamerdin JE, Tebbs RS, Schild D, Tucker JD, Shen MR, Brookman KW, Siciliano MJ, Walter CA, Fan W, Narayana LS, Zhou ZQ, Adamson AW, Sorensen KJ, Chen DJ, Jones NJ, Thompson LH (May 1998). "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages". Molecular Cell 1 (6): 783–93. doi:10.1016/S1097-2765(00)80078-7. PMID 9660962.
- Johnson RD, Liu N, Jasin M (Sep 1999). "Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination". Nature 401 (6751): 397–9. doi:10.1038/43932. PMID 10517641.
- Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (Jun 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". The Journal of Biological Chemistry 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
- Braybrooke JP, Spink KG, Thacker J, Hickson ID (Sep 2000). "The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2". The Journal of Biological Chemistry 275 (37): 29100–6. doi:10.1074/jbc.M002075200. PMID 10871607.
- O'Regan P, Wilson C, Townsend S, Thacker J (Jun 2001). "XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding". The Journal of Biological Chemistry 276 (25): 22148–53. doi:10.1074/jbc.M102396200. PMID 11301337.
- Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (Mar 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". The Journal of Biological Chemistry 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
- Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC (Dec 2001). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes & Development 15 (24): 3296–307. doi:10.1101/gad.947001. PMC 312846. PMID 11751635.
- Kurumizaka H, Ikawa S, Nakada M, Enomoto R, Kagawa W, Kinebuchi T, Yamazoe M, Yokoyama S, Shibata T (Apr 2002). "Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex". The Journal of Biological Chemistry 277 (16): 14315–20. doi:10.1074/jbc.M105719200. PMID 11834724.
- Wiese C, Collins DW, Albala JS, Thompson LH, Kronenberg A, Schild D (Feb 2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Research 30 (4): 1001–8. doi:10.1093/nar/30.4.1001. PMC 100332. PMID 11842112.
- Liu N, Schild D, Thelen MP, Thompson LH (Feb 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Research 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
- Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (Nov 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". The Journal of Biological Chemistry 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.
- Mohindra A, Bolderson E, Stone J, Wells M, Helleday T, Meuth M (Jan 2004). "A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks". Human Molecular Genetics 13 (2): 203–12. doi:10.1093/hmg/ddh022. PMID 14645207.
- Tarsounas M, Davies AA, West SC (Jan 2004). "RAD51 localization and activation following DNA damage". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 359 (1441): 87–93. doi:10.1098/rstb.2003.1368. PMC 1693300. PMID 15065660.
- Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (Jun 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Human Molecular Genetics 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
This article is issued from Wikipedia - version of the Saturday, December 12, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.