XPO5

Exportin 5

The human exportin-5 protein (red) in complex with Ran-GTP (yellow) and a pre-microRNA (green), showing two-nucleotide overhang recognition element (orange). From PDB: 3A6P.

Available structures

PDB

Ortholog search: PDBe, RCSB

List of PDB id codes
3A6P

Identifiers

Symbols

XPO5 ; exp5

External IDs

OMIM: 607845 MGI: 1913789 HomoloGene: 69316 GeneCards: XPO5 Gene

Gene ontology
Molecular function	• tRNA binding • RNA binding • mRNA binding • protein binding • Ran GTPase binding • protein transporter activity • poly(A) RNA binding • pre-miRNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • cytosol • RNA nuclear export complex
Biological process	• protein export from nucleus • gene expression • pre-miRNA export from nucleus • positive regulation of RNA interference
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
43.52 – 43.58 Mb

Chr 17:
46.2 – 46.24 Mb

PubMed search

Exportin-5 is a protein that in humans is encoded by the XPO5 gene.^[1]^[2]^[3]

Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM]^[3]

Interactions

XPO5 has been shown to interact with ILF3^[1] and Ran (biology).^[1]

References

1 2 3 Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". J Cell Biol 156 (1): 53–64. doi:10.1083/jcb.200110082. PMC 2173575. PMID 11777942.
↑ Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Gorlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". EMBO J 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMC 137205. PMID 12426392.
1 2 "Entrez Gene: XPO5 exportin 5".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Calado A, Treichel N, Müller EC, et al. (2003). "Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA". EMBO J. 21 (22): 6216–24. doi:10.1093/emboj/cdf620. PMC 137209. PMID 12426393.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gwizdek C, Ossareh-Nazari B, Brownawell AM, et al. (2003). "Exportin-5 mediates nuclear export of minihelix-containing RNAs". J. Biol. Chem. 278 (8): 5505–8. doi:10.1074/jbc.C200668200. PMID 12509441.
Screaton RA, Kiessling S, Sansom OJ, et al. (2003). "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5211–6. doi:10.1073/pnas.0431215100. PMC 154324. PMID 12702765.
Gwizdek C, Ossareh-Nazari B, Brownawell AM, et al. (2004). "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3". J. Biol. Chem. 279 (2): 884–91. doi:10.1074/jbc.M306808200. PMID 14570900.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Lund E, Güttinger S, Calado A, et al. (2004). "Nuclear export of microRNA precursors". Science 303 (5654): 95–8. doi:10.1126/science.1090599. PMID 14631048.
Yi R, Qin Y, Macara IG, Cullen BR (2004). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes Dev. 17 (24): 3011–6. doi:10.1101/gad.1158803. PMC 305252. PMID 14681208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bohnsack MT, Czaplinski K, Gorlich D (2004). "Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs". RNA 10 (2): 185–91. doi:10.1261/rna.5167604. PMC 1370530. PMID 14730017.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Chen T, Brownawell AM, Macara IG (2004). "Nucleocytoplasmic Shuttling of JAZ, a New Cargo Protein for Exportin-5". Mol. Cell. Biol. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMC 444848. PMID 15254228.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yi R, Doehle BP, Qin Y, et al. (2005). "Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs". RNA 11 (2): 220–6. doi:10.1261/rna.7233305. PMC 1370710. PMID 15613540.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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XPO5

Interactions

References

Further reading