WNT7A

Wingless-type MMTV integration site family, member 7A

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4UZQ

Identifiers

Symbol

WNT7A

External IDs

OMIM: 601570 MGI: 98961 HomoloGene: 20969 GeneCards: WNT7A Gene

Gene ontology
Molecular function	• receptor binding • frizzled binding • cytokine activity • receptor agonist activity
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum lumen • Golgi lumen • plasma membrane • cell surface
Biological process	• embryonic axis specification • cartilage condensation • angiogenesis • chondrocyte differentiation • neurotransmitter secretion • sex differentiation • asymmetric protein localization • dorsal/ventral pattern formation • positive regulation of endothelial cell migration • skeletal muscle satellite cell activation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • cerebellar granule cell differentiation • cell proliferation in forebrain • central nervous system vasculogenesis • establishment of cell polarity • neuron differentiation • regulation of axon diameter • response to estradiol • somatic stem cell maintenance • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • non-canonical Wnt signaling pathway • Wnt signaling pathway involved in wound healing, spreading of epidermal cells • embryonic digit morphogenesis • negative regulation of apoptotic process • cell fate commitment • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • somatic stem cell division • stem cell development • negative regulation of neurogenesis • synapse organization • positive regulation of synapse assembly • palate development • positive regulation of epithelial cell proliferation involved in wound healing • oviduct development • canonical Wnt signaling pathway • uterus morphogenesis • lens fiber cell development • cellular response to transforming growth factor beta stimulus • positive regulation of canonical Wnt signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
13.82 – 13.88 Mb

Chr 6:
91.36 – 91.41 Mb

PubMed search

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.^[1]^[2]^[3]

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.^[3]

References

↑ Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824.
↑ Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407.
1 2 "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A".

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409.
Huguet EL, McMahon JA, McMahon AP, et al. (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. 54 (10): 2615–21. PMID 8168088.
Parr BA, McMahon AP (1998). "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a". Nature 395 (6703): 707–10. doi:10.1038/27221. PMID 9790192.
Calvo R, West J, Franklin W, et al. (2001). "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12776–81. doi:10.1073/pnas.97.23.12776. PMC 18840. PMID 11070089.
Li S, Chiang TC, Davis GR, et al. (2001). "Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma". J. Clin. Endocrinol. Metab. 86 (1): 454–7. doi:10.1210/jc.86.1.454. PMID 11232041.
Couse JF, Dixon D, Yates M, et al. (2002). "Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract". Dev. Biol. 238 (2): 224–38. doi:10.1006/dbio.2001.0413. PMID 11784006.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Caricasole A, Ferraro T, Iacovelli L, et al. (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins". J. Biol. Chem. 278 (39): 37024–31. doi:10.1074/jbc.M300191200. PMID 12857724.
Tuli R, Tuli S, Nandi S, et al. (2003). "Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk". J. Biol. Chem. 278 (42): 41227–36. doi:10.1074/jbc.M305312200. PMID 12893825.
Ohira T, Gemmill RM, Ferguson K, et al. (2003). "WNT7a induces E-cadherin in lung cancer cells". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10429–34. doi:10.1073/pnas.1734137100. PMC 193578. PMID 12937339.
Timmreck LS, Pan HA, Reindollar RH, Gray MR (2004). "WNT7A mutations in patients with Müllerian duct abnormalities". Journal of pediatric and adolescent gynecology 16 (4): 217–21. doi:10.1016/S1083-3188(03)00124-4. PMID 14550385.
Hwang SG, Ryu JH, Kim IC, et al. (2004). "Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms". J. Biol. Chem. 279 (25): 26597–604. doi:10.1074/jbc.M401401200. PMID 15082716.
Winn RA, Marek L, Han SY, et al. (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". J. Biol. Chem. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
Lyu J, Joo CK (2005). "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing". J. Biol. Chem. 280 (22): 21653–60. doi:10.1074/jbc.M500374200. PMID 15802269.
Woods CG, Stricker S, Seemann P, et al. (2006). "Mutations in WNT7A Cause a Range of Limb Malformations, Including Fuhrmann Syndrome and Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome". Am. J. Hum. Genet. 79 (2): 402–8. doi:10.1086/506332. PMC 1559483. PMID 16826533.
Winn RA, Van Scoyk M, Hammond M, et al. (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.
Lindberg D, Akerström G, Westin G (2007). "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours". Clin. Endocrinol. (Oxf) 66 (1): 110–4. doi:10.1111/j.1365-2265.2006.02694.x. PMID 17201809.
Thrasivoulou, C, Millar, M and Ahmed, A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMID 24158438.

Signaling pathway: Wnt signaling pathway

Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16

Receptor	Frizzled LRP5 LRP6

Second messenger	Dishevelled GSK-3 APC Beta-catenin

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WNT7A

Function

References

Further reading