Vermistatin
Names | |
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IUPAC name
(3R)-4,6-Dimethoxy-3-[4-oxo-6-[(E)-prop-1-enyl]pyran-3-yl]-3H-2-benzofuran-1-one | |
Other names
5-(4,6-Dimethoxyphthalidyl)-2-propenyl-4H-pyran-4-one | |
Identifiers | |
Jmol interactive 3D | Image |
PubChem | 5467588 |
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Properties | |
C18H16O6 | |
Molar mass | 328.32 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Vermistatin is a bio-active metabolite of mine-dwelling Penicillium vermiculatum (Berkeley Pit Lake, Butte, Montana).[1] Penisimplicissin is a vermistatin analog with anticancer activity.[2]
References
- ↑ Fuska, J; Uhrín, D; Proksa, B; Votický, Z; Ruppeldt, J (1986). "The structure of vermistatin, a new metabolite from Penicillium vermiculatum". The Journal of antibiotics 39 (11): 1605–8. doi:10.7164/antibiotics.39.1605. PMID 3793630.
- ↑ Stierle AA, Stierle DB, Girtsman T (2012). "Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines.". J Nat Prod 75 (3): 344–50. doi:10.1021/np200414c. PMC 3330824. PMID 22295871.
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