VTCN1

V-set domain containing T cell activation inhibitor 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4GOS

Identifiers

Symbols

VTCN1 ; B7-H4; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1

External IDs

OMIM: 608162 MGI: 3039619 HomoloGene: 11627 GeneCards: VTCN1 Gene

Gene ontology
Molecular function	• receptor binding
Cellular component	• external side of plasma membrane • integral component of membrane
Biological process	• response to protozoan • adaptive immune response • positive regulation of T cell proliferation • negative regulation of T cell activation • interleukin-4 secretion • interferon-gamma secretion • positive regulation of interleukin-2 secretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
117.14 – 117.21 Mb

Chr 3:
100.83 – 100.9 Mb

PubMed search

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.^[1]^[2]^[3]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]^[3]

B7-H4 is an immune checkpoint molecule.

References

↑ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (Jun 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
↑ Prasad DV, Richards S, Mai XM, Dong C (Jun 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
1 2 "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

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Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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Kryczek I, Wei S, Zou L, et al. (2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.". J. Immunol. 177 (1): 40–4. PMID 16785496.
Krambeck AE, Thompson RH, Dong H, et al. (2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival.". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10391–6. doi:10.1073/pnas.0600937103. PMC 1502468. PMID 16798883.
Chen Y, Yang C, Xie Z, et al. (2007). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells.". Kidney Int. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145.
Simon I, Katsaros D, Rigault de la Longrais I, et al. (2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression.". Gynecol. Oncol. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784.
Miyatake T, Tringler B, Liu W, et al. (2007). "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration.". Gynecol. Oncol. 106 (1): 119–27. doi:10.1016/j.ygyno.2007.03.039. PMID 17509674.

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VTCN1

See also

References

Further reading