L-tryptophan—pyruvate aminotransferase

L-tryptophan---pyruvate aminotransferase (EC 2.6.1.99, TAA1 (gene), vt2 (gene)) is an enzyme with system name L-tryptophan:pyruvate aminotransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

L-tryptophan + pyruvate

\rightleftharpoons

indole-3-pyruvate + L-alanine

This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.

References

↑ Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C.L., Sandberg, G., Noel, J.P. and Chory, J. (2008). "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants". Cell 133: 164–176. doi:10.1016/j.cell.2008.01.049. PMID 18394996.
↑ Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y. and Kasahara, H. (2011). "The main auxin biosynthesis pathway in Arabidopsis". Proc. Natl. Acad. Sci. USA 108: 18512–18517. doi:10.1073/pnas.1108434108. PMC 3215075. PMID 22025724.
↑ Phillips, K.A., Skirpan, A.L., Liu, X., Christensen, A., Slewinski, T.L., Hudson, C., Barazesh, S., Cohen, J.D., Malcomber, S. and McSteen, P. (2011). "vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize". Plant Cell 23: 550–566. doi:10.1105/tpc.110.075267. PMID 21335375.
↑ Zhao, Y. (2012). "Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants". Mol. Plant 5: 334–338. doi:10.1093/mp/ssr104. PMC 3309920. PMID 22155950.

External links

L-tryptophan---pyruvate aminotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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