Uroerythrin

Uroerythrin
Names
IUPAC name
1,14,15,17-tetrahydro-2,7,13-trimethyl-1,14-dioxo-3-vinyl-16H-tripyrrin-8,12-dipropionic acid[1]
Identifiers
Jmol interactive 3D Image
Properties
C
25H
27N
3O
6
Molar mass 46.98
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroerythrin is a red pigment present in the urine, where it is part of a group of yellow, brown and red pigments generally designated as urochrome.[2]

Urinary pigments

Pigments excreted in urine are partially absorbed by urate sediments ( sedimentum latrerium ), which consists of cell debris and sedimented urinary components formed when the acidified urine is stored below room temperature.[2] These urate sediments looks reddish or pink due to the presence of a main pigment first introduced by Simons in 1842 as uroerythrin,[3]

Clinical significance

From early clinical observations it is known that uroerytrhin is present in every urine and increased amounts are observed in pathological states, e.g. metabolic disorders with high fever or tissue degradation.[4]

Chemical structure

The chemical structure of most of urochromes is still unknown, since they are very labile pigments that are easily descomposed in the light. In particular uroerythrin, remains unresolved until 1975 with previous papers that describes it like a peptidic compound.[5][6][7] In 1975 its structure was descripted in base of mass spectrometry, infrared spectroscopy and nuclear magnetic resonance.[2]

References

  1. ↑ Xiang H. Wang (2008). "Medical Use of Bilirubin and its Structural Analogues".
  2. 1 2 3 Josef BERUTER, Jean-Pierre COLOMBO, and Urs Peter SCHLUNEGGER (1975). "Isolation and Identification of the Urinary Pigment Uroerythrin". Eur. J. Biochem. 56: 239–244.
  3. ↑ Simon, J.F. (1842). Anthropochemie (Berlin): 343. Missing or empty |title= (help)
  4. ↑ Proust, L. (1800). Ann. Chem. (36): 265–269. Missing or empty |title= (help)
  5. ↑ Minder, W. (1970) Doctoral thesis, University of Berne, CH
  6. ↑ Hansen, S. E. (1969) Acta Chenz. Scand. 23, 3461-3465
  7. ↑ Hansen, S. E. (1969) Acta Chenz. Scand. 23, 3466-3472
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