UIMC1

Ubiquitin interaction motif containing 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2MKF, 2MKG, 2RR9

Identifiers

Symbols

UIMC1 ; RAP80; X2HRIP110

External IDs

OMIM: 609433 MGI: 103185 HomoloGene: 9455 GeneCards: UIMC1 Gene

Gene ontology
Molecular function	• protein binding • histone binding • K63-linked polyubiquitin binding
Cellular component	• nucleus • BRCA1-A complex
Biological process	• double-strand break repair • transcription, DNA-templated • response to ionizing radiation • G2 DNA damage checkpoint • positive regulation of DNA repair • negative regulation of transcription, DNA-templated • histone H2A K63-linked deubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
176.91 – 177.02 Mb

Chr 13:
55.03 – 55.1 Mb

PubMed search

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.^[1]^[2]

References

↑ Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.
↑ "Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis.". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wang B, Matsuoka S, Ballif BA, et al. (2007). "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.". Science 316 (5828): 1194–8. doi:10.1126/science.1139476. PMC 3573690. PMID 17525340.
Sobhian B, Shao G, Lilli DR, et al. (2007). "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.". Science 316 (5828): 1198–202. doi:10.1126/science.1139516. PMC 2706583. PMID 17525341.
Kim H, Chen J, Yu X (2007). "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.". Science 316 (5828): 1202–5. doi:10.1126/science.1139621. PMID 17525342.
Shebzukhov YV, Koroleva EP, Khlgatian SV, et al. (2007). "RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity.". Cancer Lett. 255 (2): 255–62. doi:10.1016/j.canlet.2007.04.013. PMID 17562356.
Yan J, Kim YS, Yang XP, et al. (2007). "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.". Cancer Res. 67 (14): 6647–56. doi:10.1158/0008-5472.CAN-07-0924. PMC 2391092. PMID 17621610.
Yan J, Yang XP, Kim YS, et al. (2007). "RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.". Biochem. Biophys. Res. Commun. 362 (1): 132–8. doi:10.1016/j.bbrc.2007.07.158. PMC 2049087. PMID 17698038.

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UIMC1

References

Further reading