Thioesterase

Thioesterases are enzymes which belong to the Esterase family. Esterases, in turn, are one type of the several hydrolases known.

Thioesterases exhibit Esterase activity (splitting of an ester into acid and alcohol, in the presence of water) specifically at a thiol group.

Thioesterases or thiolester hydrolases are identified as members of E.C.3.1.2.

Examples

Acetyl-coA hydrolase, palmitoyl-coA hydrolase, succinyl-coA hydrolase, formyl-coA hydrolase, acyl-coA hydrolase are a few examples of this group of enzymes.

Ubiquitin thiolesterase is a well-known example, whose structure has been analyzed.

Humans genes which encode thiolesterases include:^[1]

ACOT1, ACOT2, ACOT4, ACOT6, ACOT7, ACOT8, Acyl-CoA Thioesterase 9, ACOT11(STARD14), ACOT12 (STARD15), OLAH, PPT1, PPT2, THEM2 (ACOT13), THEM4, THEM4P1, THEM5

References

↑ Brocker, C; Carpenter, C; Nebert, DW; Vasiliou, V (Aug 2010). "Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family.". Human Genomics 4 (6): 411–20. PMC 3525216. PMID 20846931.

External links

thioesterase I at the US National Library of Medicine Medical Subject Headings (MeSH)
thioesterase II at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

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