Thelephoric acid
 | |
 | |
| Names | |
|---|---|
| IUPAC name
2,3,8,9-Tetrahydroxybenzo[b][1]benzofuro[2,3-f][1]benzofuran-6,12-dione | |
| Identifiers | |
| ChemSpider | 30776833 |
| Jmol interactive 3D | Image |
| |
| |
| Properties | |
| C18H8O8 | |
| Molar mass | 352.25 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Thelephoric acid is a terphenylquinone pigment that is found in several fungi, such as Omphalotus subilludens[1] and Polyozellus multiplex.[2] Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[3][4]
References
- ↑ Sullivan G, Garrett RD, Lenehan RF. (1971). "Occurrence of atromentin and thelephoric acid in cultures of Clitocybe subilludens". Journal of Pharmaceutical Sciences 60 (11): 1727–29. doi:10.1002/jps.2600601134. PMID 4332377.
- ↑ Ju-Yeon K, Rhee I-K, Lee K-B, Hwang J-S, Yoo I-D, Song K-S. (1999). "Thelephoric acid and kynapcin-9 in mushroom Polyozellus multiflex inhibit prolyl endopeptidase in vitro". Journal of Microbiology and Biotechnology 9 (6): 798–803.
- ↑ Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. doi:10.7164/antibiotics.50.773. PMID 9360624.
- ↑ Nagasawa I, Kaneko A, Suzuki T, Nishio K, Kinoshita K, Shiro M, Koyama K. (2014). "Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex". Journal of Natural Products 77 (4): 963–8. doi:10.1021/np401046z. PMID 24601669.
This article is issued from Wikipedia - version of the Tuesday, July 07, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.