Tetrazolylglycine

Tetrazolylglycine

Names
IUPAC name (RS)-amino(1H-tetrazol-5-yl)acetic acid
Identifiers
CAS Number	138199-51-6
ChEMBL	ChEMBL140784 Y
ChemSpider	112321 Y
IUPHAR/BPS	4068
Jmol interactive 3D	Image
PubChem	126383
InChI InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8) Y Key: UKBRUIZWQZHXFL-UHFFFAOYSA-N Y InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8) Key: UKBRUIZWQZHXFL-UHFFFAOYAB
SMILES O=C(O)C(N)c1nnnn1
Properties
Chemical formula	C3H5N5O2
Molar mass	143.104
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA.^[1] It is a potent convulsant and excitotoxin and is used in scientific research.^[2][3]

References

1. ↑ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. Journal of Medicinal Chemistry. 1992 Nov 27;35(24):4608-12. PMID 1361579
2. ↑ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. European Journal of Pharmacology. 1991 Oct 15;203(2):237-43. PMID 1686860
3. ↑ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. European Journal of Pharmacology. 1994 Jan 3;270(1):67-72. PMID 8157082