Terpentedienyl-diphosphate synthase

Terpentedienyl-diphosphate synthase (EC 5.5.1.15, terpentedienol diphosphate synthase, Cyc1, clerodadienyl diphosphate synthase) is an enzyme with system name terpentedienyl-diphosphate lyase (decyclizing).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate

\rightleftharpoons

terpentedienyl diphosphate

This enzyme requires Mg²⁺.

References

↑ Dairi, T., Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K. and Seto, H. (2001). "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin". J. Bacteriol. 183: 6085–6094. doi:10.1128/jb.183.20.6085-6094.2001. PMID 11567009.
↑ Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K., Seto, H. and Dairi, T. (2002). "Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin". J. Biol. Chem. 277: 37098–37104. doi:10.1074/jbc.m206382200. PMID 12138123.
↑ Eguchi, T., Dekishima, Y., Hamano, Y., Dairi, T., Seto, H. and Kakinuma, K. (2003). "A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and ¹H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase". J. Org. Chem. 68: 5433–5438. doi:10.1021/jo026728a. PMID 12839434.

External links

Terpentedienyl-diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: Intramolecular Lyases (EC 5.5)

5.5.1 Intramolecular Lyases

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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