TAL1
T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.[1][2]
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.
Interactions
TAL1 has been shown to interact with:
References
- ↑ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
- ↑ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
- 1 2 3 4 5 Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
- ↑ Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
- 1 2 Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
- 1 2 Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
- 1 2 Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052.
- ↑ Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
- ↑ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
- ↑ Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
Further reading
- Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors.". Int. J. Cell Cloning 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013.
- Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.". Blood 79 (5): 1327–33. PMID 1311214.
- Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation.". EMBO J. 11 (11): 4073–81. PMC 556917. PMID 1396592.
- Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858–66. PMID 1450410.
- Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.". Oncogene 6 (8): 1477–88. PMID 1886719.
- Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.". Genes Chromosomes Cancer 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581.
- Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650.
- Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus.". Mol. Cell. Biol. 10 (12): 6426–35. PMC 362919. PMID 2247063.
- Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". EMBO J. 9 (2): 415–24. PMC 551682. PMID 2303035.
- Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361.
- Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
- Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues.". Blood 85 (3): 675–84. PMID 7833471.
- Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052.
- Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
- Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.". Oncogene 9 (10): 3013–6. PMID 8084606.
- Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
- Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.". Oncogene 8 (11): 3043–6. PMID 8414504.
- Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.". Mol. Cell. Biol. 13 (2): 801–8. PMC 358963. PMID 8423803.
External links
- TAL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook TAL1
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