TXNRD1

Thioredoxin reductase 1

PDB rendering based on 1h6v.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1W1C, 2CFY, 2J3N, 2ZZ0, 2ZZB, 2ZZC, 3QFA, 3QFB

Identifiers

Symbols

TXNRD1 ; GRIM-12; TR; TR1; TRXR1; TXNR

External IDs

OMIM: 601112 MGI: 1354175 HomoloGene: 55733 ChEMBL: 1927 GeneCards: TXNRD1 Gene

EC number

1.8.1.9

Gene ontology
Molecular function	• thioredoxin-disulfide reductase activity • protein binding • electron carrier activity • protein disulfide oxidoreductase activity • flavin adenine dinucleotide binding
Cellular component	• nucleoplasm • nucleolus • mitochondrion • cytosol • extracellular exosome
Biological process	• response to reactive oxygen species • mesoderm formation • transcription initiation from RNA polymerase II promoter • signal transduction • cell proliferation • gene expression • nucleobase-containing small molecule interconversion • cellular lipid metabolic process • small molecule metabolic process • cell redox homeostasis • nucleobase-containing small molecule metabolic process • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
104.22 – 104.35 Mb

Chr 10:
82.86 – 82.9 Mb

PubMed search

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene.^[1]

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.^[2]

References

↑ Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett 373 (1): 5–9. doi:10.1016/0014-5793(95)01003-W. PMID 7589432.
↑ "Entrez Gene: TXNRD1 thioredoxin reductase 1".

PDB gallery

1h6v: MAMMALIAN THIOREDOXIN REDUCTASE

2cfy: CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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TXNRD1

See also

References