TSPAN13
| Tetraspanin 13 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TSPAN13 ; NET-6; NET6; TM4SF13 | ||||||||||||
| External IDs | OMIM: 613139 MGI: 1913359 HomoloGene: 8671 GeneCards: TSPAN13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 27075 | 66109 | |||||||||||
| Ensembl | ENSG00000106537 | ENSMUSG00000020577 | |||||||||||
| UniProt | O95857 | Q9D8C2 | |||||||||||
| RefSeq (mRNA) | NM_014399 | NM_025359 | |||||||||||
| RefSeq (protein) | NP_055214 | NP_079635 | |||||||||||
| Location (UCSC) |
Chr 7: 16.75 – 16.78 Mb |
Chr 12: 36.01 – 36.04 Mb | |||||||||||
| PubMed search | |||||||||||||
Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.[1]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[1]
References
Further reading
- Böhme E, Graf H, Schultz G (1978). "Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets". Advances in cyclic nucleotide research 9: 131–43. PMID 27075.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Serru V, Dessen P, Boucheix C, Rubinstein E (2000). "Sequence and expression of seven new tetraspans". Biochim. Biophys. Acta 1478 (1): 159–63. doi:10.1016/S0167-4838(00)00022-4. PMID 10719184.
- Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Huang H, Groth J, Sossey-Alaoui K, et al. (2005). "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi:10.1158/1078-0432.CCR-04-2107. PMID 15958618.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Moroz MA, Serganova I, Zanzonico P, et al. (2007). "Imaging hNET reporter gene expression with 124I-MIBG". J. Nucl. Med. 48 (5): 827–36. doi:10.2967/jnumed.106.037812. PMID 17475971.
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