TRPV6

Transient receptor potential cation channel, subfamily V, member 6

Identifiers

TRPV6 ; ABP/ZF; CAT1; CATL; ECAC2; HSA277909; LP6728; ZFAB

External IDs

OMIM: 606680 MGI: 1927259 HomoloGene: 56812 IUPHAR: 512 ChEMBL: 1628465 GeneCards: TRPV6 Gene

Gene ontology
Molecular function	• calcium channel activity • protein binding • calmodulin binding
Cellular component	• plasma membrane • integral component of plasma membrane • extracellular exosome
Biological process	• calcium ion transport • regulation of calcium ion-dependent exocytosis • ion transmembrane transport • parathyroid hormone secretion • calcium ion homeostasis • transmembrane transport • calcium ion transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
142.87 – 142.89 Mb

Chr 6:
41.62 – 41.64 Mb

PubMed search

TRPV6 is a membrane calcium channel which is particularly involved in the first step in calcium absorption in the intestine.

Nomenclature

When first discovered it was named CAT1,^[1] or ECaC2.^[2] The name TRPV6 was confirmed in 2005.^[3]

TRPV6 is a member of the transient receptor potential (TRP) family of membrane proteins. Unlike most TRP channels, TRPV6 is selective for Ca²⁺ ions, a property shared with its close homologue, TRPV5, which is mainly expressed in the kidney and plays a role in renal Ca²⁺ reabsorption.^[4]

Expression

TRPV6 expression has been described in the intestine in several species, including humans.^[5] The protein is located in the apical brush-border membrane of the intestinal enterocyte where it regulates calcium entry into the cell. It is most abundant in the proximal small intestine (duodenum and jejunum), along with the other calcium transport proteins, calbindin and the calcium-pumping ATPase, PMCA1. The TRPV6 calcium transporter also found in the human placenta, pancreas and prostate gland and in some species in the kidney, where the related channel TRPV5 is strongly expressed.

Regulation of expression

Vitamin D

Expression of TRPV6 is vitamin D dependent in mice and humans. Its expression was greatly reduced in animals that do not express the vitamin D receptor.^[6]

Vitamin D treatment of human colon cancer cells, Caco-2, increased expression of TRPV6 transcripts, and also stimulated the transport of calcium, probably through increased TRPV6 expression.^[7] In human duodenal explants, TRPV6 transcript expression was increased 3-fold after 6h incubation with the active form of vitamin D, 1,25-dihydroxycholecalciferol.^[8]

References

↑ Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA (August 1999). "Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption". J. Biol. Chem. 274 (32): 22739–46. doi:10.1074/jbc.274.32.22739. PMID 10428857.
↑ Weber K, Erben RG, Rump A, Adamski J (December 2001). "Gene structure and regulation of the murine epithelial calcium channels ECaC1 and 2". Biochem. Biophys. Res. Commun. 289 (5): 1287–94. doi:10.1006/bbrc.2001.6121. PMID 11741335.
↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
↑ Peng JB, Brown EM, Hediger MA (September 2003). "Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond". J. Physiol. (Lond.) 551 (Pt 3): 729–40. doi:10.1113/jphysiol.2003.043349. PMC 2343303. PMID 12869611.
↑ Barley NF, Howard A, O'Callaghan D, Legon S, Walters JR (February 2001). "Epithelial calcium transporter expression in human duodenum". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2): G285–90. PMID 11208552.
↑ Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, Carmeliet G (November 2001). "Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 13324–9. doi:10.1073/pnas.231474698. PMC 60869. PMID 11687634.
↑ Taparia S, Fleet JC, Peng JB, Wang XD, Wood RJ (June 2006). "1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D--mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells". Eur J Nutr 45 (4): 196–204. doi:10.1007/s00394-005-0586-3. PMID 16362534.
↑ Balesaria S, Sangha S, Walters JR (December 2009). "Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (6): G1193–7. doi:10.1152/ajpgi.00237.2009. PMC 2850091. PMID 19779013.

External links

TRPV Cation Channels at the US National Library of Medicine Medical Subject Headings (MeSH)
TRPV6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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