TRIP11

Thyroid hormone receptor interactor 11
Identifiers
Symbols TRIP11 ; ACG1A; CEV14; GMAP-210; GMAP210; TRIP-11; TRIP230
External IDs OMIM: 604505 MGI: 1924393 HomoloGene: 20897 GeneCards: TRIP11 Gene
Orthologs
Species Human Mouse
Entrez 9321 109181
Ensembl ENSG00000100815 ENSMUSG00000021188
UniProt Q15643 E9Q4A9
RefSeq (mRNA) NM_004239 NM_028446
RefSeq (protein) NP_004230 NP_082722
Location (UCSC) Chr 14:
91.97 – 92.04 Mb
Chr 12:
101.83 – 101.91 Mb
PubMed search

Thyroid receptor-interacting protein 11 is a protein that in humans is encoded by the TRIP11 gene.[1][2][3]

Function

TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus and microtubules.[supplied by OMIM][3]

Interactions

TRIP11 has been shown to interact with Retinoblastoma protein[4] and Thyroid hormone receptor alpha.[4]

References

  1. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
  2. Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H (Dec 1997). "Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution". Blood 90 (11): 4271–7. PMID 9373237.
  3. 1 2 "Entrez Gene: TRIP11 thyroid hormone receptor interactor 11".
  4. 1 2 Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.

Further reading


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