TNPO2
| Transportin 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TNPO2 ; IPO3; KPNB2B; TRN2 | ||||||||||||
| External IDs | OMIM: 603002 MGI: 2384849 HomoloGene: 8381 GeneCards: TNPO2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 30000 | 212999 | |||||||||||
| Ensembl | ENSG00000105576 | ENSMUSG00000031691 | |||||||||||
| UniProt | O14787 | Q99LG2 | |||||||||||
| RefSeq (mRNA) | NM_001136195 | NM_001122843 | |||||||||||
| RefSeq (protein) | NP_001129667 | NP_001116315 | |||||||||||
| Location (UCSC) |
Chr 19: 12.7 – 12.72 Mb |
Chr 8: 85.04 – 85.06 Mb | |||||||||||
| PubMed search | |||||||||||||
Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.[1][2][3]
Interactions
TNPO2 has been shown to interact with NXF1,[2] NUP98[4] and Ran (biology).[2]
References
- ↑ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (October 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". J Cell Biol 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
- 1 2 3 Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proc Natl Acad Sci U S A 99 (22): 14195–9. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
- ↑ "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
- ↑ Fontoura, B M; Blobel G; Yaseen N R (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. (UNITED STATES) 275 (40): 31289–96. doi:10.1074/jbc.M004651200. ISSN 0021-9258. PMID 10875935.
Further reading
- Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides.". Science 294 (5548): 1895–901. doi:10.1126/science.1064693. PMID 11729309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Blanc V, Kennedy S, Davidson NO (2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.". J. Biol. Chem. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Güttinger S, Mühlhäusser P, Koller-Eichhorn R, et al. (2004). "Transportin2 functions as importin and mediates nuclear import of HuR.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2918–23. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
- Rebane A, Aab A, Steitz JA (2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.". RNA 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
- Lee BJ, Cansizoglu AE, Süel KE, et al. (2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2.". Cell 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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