TGF beta 2

Transforming growth factor, beta 2
PDB rendering based on 1tfg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1TFG​, 2TGI​, 4KXZ​
Identifiers
Symbols	TGFB2 ; LDS4; TGF-beta2
External IDs	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2 Gene
Gene ontology Molecular function • beta-amyloid binding • receptor signaling protein serine/threonine kinase activity • receptor binding • type II transforming growth factor beta receptor binding • cytokine activity • transforming growth factor beta receptor binding • protein binding • growth factor activity • type III transforming growth factor beta receptor binding • protein homodimerization activity • protein heterodimerization activity Cellular component • extracellular region • extracellular space • endosome • axon • extracellular matrix • platelet alpha granule lumen • neuronal cell body Biological process • cell morphogenesis • cartilage condensation • angiogenesis • eye development • response to hypoxia • epithelial to mesenchymal transition • hair follicle development • blood vessel remodeling • platelet degranulation • heart morphogenesis • heart valve morphogenesis • protein phosphorylation • cell cycle arrest • transforming growth factor beta receptor signaling pathway • SMAD protein import into nucleus • cell-cell signaling • axon guidance • salivary gland morphogenesis • heart development • blood coagulation • cell death • cell proliferation • positive regulation of cell proliferation • negative regulation of cell proliferation • glial cell migration • response to wounding • embryo development • cardioblast differentiation • positive regulation of gene expression • positive regulation of epithelial cell migration • negative regulation of alkaline phosphatase activity • positive regulation of epithelial to mesenchymal transition • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of macrophage cytokine production • positive regulation of phosphatidylinositol 3-kinase signaling • cell growth • cell migration • signal transduction by protein phosphorylation • hemopoiesis • platelet activation • extracellular matrix organization • collagen fibril organization • positive regulation of cell growth • negative regulation of cell growth • neutrophil chemotaxis • hair follicle morphogenesis • activation of protein kinase activity • response to progesterone • positive regulation of stress-activated MAPK cascade • regulation of transforming growth factor beta2 production • positive regulation of cell adhesion mediated by integrin • wound healing • dopamine biosynthetic process • odontogenesis • response to drug • catagen • uterine wall breakdown • positive regulation of neuron apoptotic process • cell-cell junction organization • positive regulation of integrin biosynthetic process • positive regulation of ossification • positive regulation of cell cycle • positive regulation of heart contraction • somatic stem cell division • cell development • embryonic digestive tract development • neuron fate commitment • neuron development • generation of neurons • negative regulation of epithelial cell proliferation • positive regulation of protein secretion • negative regulation of immune response • positive regulation of immune response • positive regulation of cell division • positive regulation of catagen • positive regulation of cardioblast differentiation • cardiac muscle cell proliferation • cardiac epithelial to mesenchymal transition • face morphogenesis • pathway-restricted SMAD protein phosphorylation • SMAD protein signal transduction • negative regulation of cartilage development • positive regulation of activation-induced cell death of T cells • extrinsic apoptotic signaling pathway • regulation of extracellular matrix organization • regulation of complement-dependent cytotoxicity • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7042	21808
Ensembl	ENSG00000092969	ENSMUSG00000039239
UniProt	P61812	P27090
RefSeq (mRNA)	NM_001135599	NM_009367
RefSeq (protein)	NP_001129071	NP_033393
Location (UCSC)	Chr 1: 218.35 – 218.44 Mb	Chr 1: 186.62 – 186.71 Mb
PubMed search

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

Further reading

PDB gallery 1tfg: AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2  2tgi: CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY