TFDP2

Transcription factor Dp-2 (E2F dimerization partner 2)

PDB rendering based on 1cf7.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1CF7

Identifiers

Symbols

TFDP2 ; DP2

External IDs

OMIM: 602160 MGI: 107167 HomoloGene: 4578 GeneCards: TFDP2 Gene

Gene ontology
Molecular function	• RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription cofactor activity • protein binding • transcription factor binding • protein domain specific binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex
Biological process	• mitotic cell cycle • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • Notch signaling pathway • gene expression • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
141.94 – 142.15 Mb

Chr 9:
96.2 – 96.32 Mb

PubMed search

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene.^[1]^[2]^[3]

References

↑ Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene 10 (11): 2085–93. PMID 7784053.
↑ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
↑ "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. PMC 230484. PMID 7739537.
Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
Loiseau L, Pasteau S, Brun G (1998). "Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor". Gene Expr. 6 (5): 259–73. PMID 9368098.
Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
Gaubatz S, Wood JG, Livingston DM (1998). "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9190–5. doi:10.1073/pnas.95.16.9190. PMC 21314. PMID 9689056.
Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551. PMID 10090723.
Korz C, Pscherer A, Benner A, et al. (2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Park KK, Deok Ahn J, Lee IK, et al. (2003). "Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP". Biochem. Biophys. Res. Commun. 308 (4): 689–97. doi:10.1016/S0006-291X(03)01455-4. PMID 12927774.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1cf7: STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP

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TFDP2

References

Further reading